LYZL4_HUMAN
ID LYZL4_HUMAN Reviewed; 146 AA.
AC Q96KX0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Lysozyme-like protein 4;
DE Short=Lysozyme-4;
DE Flags: Precursor;
GN Name=LYZL4; Synonyms=LYC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=16014814; DOI=10.1095/biolreprod.105.041889;
RA Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L.;
RT "Molecular cloning and characterization of three novel lysozyme-like genes,
RT predominantly expressed in the male reproductive system of humans,
RT belonging to the c-type lysozyme/alpha-lactalbumin family.";
RL Biol. Reprod. 73:1064-1071(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- FUNCTION: May be involved in fertilization (By similarity). Has no
CC detectable bacteriolytic and lysozyme activities in vitro (By
CC similarity). {ECO:0000250|UniProtKB:D4ABW7,
CC ECO:0000250|UniProtKB:Q9D925}.
CC -!- SUBUNIT: Monomer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D925}.
CC Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000250|UniProtKB:Q9D925}. Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q9D925}. Note=Found in the principal piece of
CC sperm tail. {ECO:0000250|UniProtKB:Q9D925}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and epididymis.
CC {ECO:0000269|PubMed:16014814}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00680}.
CC -!- CAUTION: Although it belongs to the glycosyl hydrolase 22 family, Gly-
CC 72 is present instead of the conserved Asp which is an active site
CC residue. It is therefore expected that this protein lacks hydrolase
CC activity. {ECO:0000305}.
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DR EMBL; AF326749; AAO32946.1; -; mRNA.
DR EMBL; AC092048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016747; AAH16747.1; -; mRNA.
DR CCDS; CCDS2697.1; -.
DR RefSeq; NP_001291315.1; NM_001304386.1.
DR RefSeq; NP_653235.1; NM_144634.3.
DR RefSeq; XP_016861194.1; XM_017005705.1.
DR RefSeq; XP_016861195.1; XM_017005706.1.
DR AlphaFoldDB; Q96KX0; -.
DR SMR; Q96KX0; -.
DR BioGRID; 126277; 1.
DR STRING; 9606.ENSP00000287748; -.
DR CAZy; GH22; Glycoside Hydrolase Family 22.
DR iPTMnet; Q96KX0; -.
DR PhosphoSitePlus; Q96KX0; -.
DR BioMuta; LYZL4; -.
DR DMDM; 74732223; -.
DR MassIVE; Q96KX0; -.
DR PaxDb; Q96KX0; -.
DR PeptideAtlas; Q96KX0; -.
DR PRIDE; Q96KX0; -.
DR ProteomicsDB; 77127; -.
DR Antibodypedia; 29191; 97 antibodies from 20 providers.
DR DNASU; 131375; -.
DR Ensembl; ENST00000287748.8; ENSP00000287748.3; ENSG00000157093.9.
DR Ensembl; ENST00000441172.1; ENSP00000387897.1; ENSG00000157093.9.
DR GeneID; 131375; -.
DR KEGG; hsa:131375; -.
DR MANE-Select; ENST00000287748.8; ENSP00000287748.3; NM_144634.4; NP_653235.1.
DR UCSC; uc003cle.4; human.
DR CTD; 131375; -.
DR DisGeNET; 131375; -.
DR GeneCards; LYZL4; -.
DR HGNC; HGNC:28387; LYZL4.
DR HPA; ENSG00000157093; Tissue enriched (testis).
DR MIM; 612750; gene.
DR neXtProt; NX_Q96KX0; -.
DR OpenTargets; ENSG00000157093; -.
DR PharmGKB; PA134911368; -.
DR VEuPathDB; HostDB:ENSG00000157093; -.
DR eggNOG; ENOG502SSER; Eukaryota.
DR GeneTree; ENSGT00940000162293; -.
DR HOGENOM; CLU_111620_1_1_1; -.
DR InParanoid; Q96KX0; -.
DR OMA; AWPSWSL; -.
DR OrthoDB; 1551203at2759; -.
DR PhylomeDB; Q96KX0; -.
DR TreeFam; TF324882; -.
DR PathwayCommons; Q96KX0; -.
DR SignaLink; Q96KX0; -.
DR BioGRID-ORCS; 131375; 31 hits in 1059 CRISPR screens.
DR GenomeRNAi; 131375; -.
DR Pharos; Q96KX0; Tbio.
DR PRO; PR:Q96KX0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96KX0; protein.
DR Bgee; ENSG00000157093; Expressed in sperm and 47 other tissues.
DR ExpressionAtlas; Q96KX0; baseline and differential.
DR Genevisible; Q96KX0; HS.
DR GO; GO:0001669; C:acrosomal vesicle; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR GO; GO:0003796; F:lysozyme activity; IEA:InterPro.
DR GO; GO:0009566; P:fertilization; ISS:UniProtKB.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IBA:GO_Central.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR030062; LYZL4.
DR PANTHER; PTHR11407; PTHR11407; 1.
DR PANTHER; PTHR11407:SF21; PTHR11407:SF21; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasmic vesicle; Disulfide bond;
KW Fertilization; Flagellum; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..146
FT /note="Lysozyme-like protein 4"
FT /id="PRO_0000240638"
FT DOMAIN 20..146
FT /note="C-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 25..144
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 49..131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 84..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 92..110
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
SQ SEQUENCE 146 AA; 16433 MW; 2A1821ED2153E682 CRC64;
MKASVVLSLL GYLVVPSGAY ILGRCTVAKK LHDGGLDYFE GYSLENWVCL AYFESKFNPM
AIYENTREGY TGFGLFQMRG SDWCGDHGRN RCHMSCSALL NPNLEKTIKC AKTIVKGKEG
MGAWPTWSRY CQYSDTLARW LDGCKL
