ID   LYZL5_BOVIN             Reviewed;         156 AA.
AC   Q32PD6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Sperm acrosome-associated protein 5;
DE            EC=3.2.1.17;
DE   AltName: Full=Lysozyme-like protein 5;
DE   Flags: Precursor;
GN   Name=SPACA5; Synonyms=LYZL5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00680}.
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DR   EMBL; BC108157; AAI08158.1; -; mRNA.
DR   RefSeq; NP_001035626.1; NM_001040536.2.
DR   AlphaFoldDB; Q32PD6; -.
DR   SMR; Q32PD6; -.
DR   STRING; 9913.ENSBTAP00000055963; -.
DR   CAZy; GH22; Glycoside Hydrolase Family 22.
DR   PaxDb; Q32PD6; -.
DR   Ensembl; ENSBTAT00000063388; ENSBTAP00000055963; ENSBTAG00000046069.
DR   GeneID; 517880; -.
DR   KEGG; bta:517880; -.
DR   CTD; 389852; -.
DR   VEuPathDB; HostDB:ENSBTAG00000046069; -.
DR   eggNOG; ENOG502SUHW; Eukaryota.
DR   GeneTree; ENSGT00940000162205; -.
DR   HOGENOM; CLU_111620_0_1_1; -.
DR   InParanoid; Q32PD6; -.
DR   OMA; SAWWCNN; -.
DR   OrthoDB; 1551203at2759; -.
DR   TreeFam; TF324882; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000046069; Expressed in semen and 13 other tissues.
DR   ExpressionAtlas; Q32PD6; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001916; Glyco_hydro_22.
DR   InterPro; IPR000974; Glyco_hydro_22_lys.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR030064; LYZL5.
DR   PANTHER; PTHR11407; PTHR11407; 1.
DR   PANTHER; PTHR11407:SF31; PTHR11407:SF31; 1.
DR   Pfam; PF00062; Lys; 1.
DR   PRINTS; PR00137; LYSOZYME.
DR   PRINTS; PR00135; LYZLACT.
DR   SMART; SM00263; LYZ1; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
DR   PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..156
FT                   /note="Sperm acrosome-associated protein 5"
FT                   /id="PRO_0000284469"
FT   DOMAIN          19..147
FT                   /note="C-type lysozyme"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT   ACT_SITE        53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT   DISULFID        24..144
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT   DISULFID        48..132
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT   DISULFID        82..97
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT   DISULFID        93..111
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
SQ   SEQUENCE   156 AA;  17580 MW;  427670D8003EA25E CRC64;
     MQVSGTIVVI LMAANVEAKI YERCDLAKKL EAAGLNGFKG YTIGDWLCMA HYESGFDTSF
     VNHNPDGSSE YGIFQLNSAW WCYNGVTPSE NLCHMDCHEL LNRHILDDIM CAKKVVSSES
     GMSAWDSWNQ HCYGYDLSEW LRGCHMNAKP NKKIIS