LYZL5_HUMAN
ID LYZL5_HUMAN Reviewed; 159 AA.
AC Q96QH8; Q6UWD1;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Sperm acrosome-associated protein 5;
DE EC=3.2.1.17;
DE AltName: Full=Lysozyme-like protein 5;
DE AltName: Full=Sperm-specific lysozyme-like protein X;
DE Short=SLLP-X;
DE Flags: Precursor;
GN Name=SPACA5; Synonyms=LYZL5, SPACA5A; ORFNames=UNQ6288/PRO20753;
GN and
GN Name=SPACA5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Mandal A., Herr J.C.;
RT "Cloning of a novel lysozyme like human sperm-specific secretory protein
RT SLLP-X which maps to the X chromosome.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP IDENTIFICATION.
RX PubMed=16382448; DOI=10.1002/gcc.20298;
RA Chen Y.-T., Iseli C., Venditti C.A., Old L.J., Simpson A.J.G.,
RA Jongeneel C.V.;
RT "Identification of a new cancer/testis gene family, CT47, among expressed
RT multicopy genes on the human X chromosome.";
RL Genes Chromosomes Cancer 45:392-400(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00680}.
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DR EMBL; AF217622; AAQ13890.1; -; mRNA.
DR EMBL; AY358844; AAQ89203.1; -; mRNA.
DR EMBL; Z98304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356464; CAI40526.1; -; Genomic_DNA.
DR CCDS; CCDS14286.1; -.
DR CCDS; CCDS35238.1; -.
DR RefSeq; NP_001073369.1; NM_001079900.1.
DR RefSeq; NP_995328.2; NM_205856.3.
DR RefSeq; XP_016885001.1; XM_017029512.1.
DR AlphaFoldDB; Q96QH8; -.
DR SMR; Q96QH8; -.
DR STRING; 9606.ENSP00000304762; -.
DR CAZy; GH22; Glycoside Hydrolase Family 22.
DR iPTMnet; Q96QH8; -.
DR PhosphoSitePlus; Q96QH8; -.
DR BioMuta; SPACA5B; -.
DR DMDM; 74761053; -.
DR MassIVE; Q96QH8; -.
DR PaxDb; Q96QH8; -.
DR PeptideAtlas; Q96QH8; -.
DR PRIDE; Q96QH8; -.
DR ProteomicsDB; 77880; -.
DR Antibodypedia; 67548; 60 antibodies from 11 providers.
DR Antibodypedia; 73808; 34 antibodies from 5 providers.
DR DNASU; 389852; -.
DR DNASU; 729201; -.
DR Ensembl; ENST00000304270.6; ENSP00000304762.5; ENSG00000171478.8.
DR Ensembl; ENST00000304355.9; ENSP00000305847.5; ENSG00000171489.11.
DR Ensembl; ENST00000376940.4; ENSP00000366139.3; ENSG00000171489.11.
DR GeneID; 389852; -.
DR GeneID; 729201; -.
DR KEGG; hsa:389852; -.
DR KEGG; hsa:729201; -.
DR MANE-Select; ENST00000304270.6; ENSP00000304762.5; NM_001079900.2; NP_001073369.1.
DR MANE-Select; ENST00000376940.4; ENSP00000366139.3; NM_001394298.1; NP_001381227.1.
DR UCSC; uc004diu.5; human.
DR CTD; 389852; -.
DR CTD; 729201; -.
DR GeneCards; SPACA5; -.
DR GeneCards; SPACA5B; -.
DR HGNC; HGNC:31353; SPACA5.
DR HGNC; HGNC:19142; SPACA5B.
DR HPA; ENSG00000171478; Tissue enriched (testis).
DR HPA; ENSG00000171489; Tissue enriched (testis).
DR MIM; 300593; gene.
DR neXtProt; NX_Q96QH8; -.
DR OpenTargets; ENSG00000171489; -.
DR PharmGKB; PA162404365; -.
DR VEuPathDB; HostDB:ENSG00000171478; -.
DR VEuPathDB; HostDB:ENSG00000171489; -.
DR eggNOG; ENOG502SUHW; Eukaryota.
DR GeneTree; ENSGT00940000162205; -.
DR HOGENOM; CLU_111620_0_1_1; -.
DR InParanoid; Q96QH8; -.
DR OMA; SAWWCNN; -.
DR OrthoDB; 1551203at2759; -.
DR PhylomeDB; Q96QH8; -.
DR TreeFam; TF324882; -.
DR PathwayCommons; Q96QH8; -.
DR BioGRID-ORCS; 389852; 9 hits in 237 CRISPR screens.
DR BioGRID-ORCS; 729201; 3 hits in 183 CRISPR screens.
DR Pharos; Q96QH8; Tdark.
DR PRO; PR:Q96QH8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96QH8; protein.
DR Bgee; ENSG00000171478; Expressed in left testis and 67 other tissues.
DR ExpressionAtlas; Q96QH8; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR030064; LYZL5.
DR PANTHER; PTHR11407; PTHR11407; 1.
DR PANTHER; PTHR11407:SF31; PTHR11407:SF31; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..159
FT /note="Sperm acrosome-associated protein 5"
FT /id="PRO_0000284470"
FT DOMAIN 22..150
FT /note="C-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 27..147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 51..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 85..100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 96..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT CONFLICT 26
FT /note="R -> L (in Ref. 1; AAQ89203)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 17896 MW; DD081C9CB5946277 CRC64;
MKAWGTVVVT LATLMVVTVD AKIYERCELA ARLERAGLNG YKGYGVGDWL CMAHYESGFD
TAFVDHNPDG SSEYGIFQLN SAWWCDNGIT PTKNLCHMDC HDLLNRHILD DIRCAKQIVS
SQNGLSAWTS WRLHCSGHDL SEWLKGCDMH VKIDPKIHP
