LYZL5_MOUSE
ID LYZL5_MOUSE Reviewed; 160 AA.
AC A2AE20;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Sperm acrosome-associated protein 5;
DE EC=3.2.1.17;
DE AltName: Full=Lysozyme-like protein 5;
DE Flags: Precursor;
GN Name=Spaca5; Synonyms=Gm718, Lyzl5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00680}.
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DR EMBL; AL671853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS40888.1; -.
DR RefSeq; NP_001078862.1; NM_001085393.2.
DR AlphaFoldDB; A2AE20; -.
DR SMR; A2AE20; -.
DR STRING; 10090.ENSMUSP00000048721; -.
DR CAZy; GH22; Glycoside Hydrolase Family 22.
DR PhosphoSitePlus; A2AE20; -.
DR jPOST; A2AE20; -.
DR PaxDb; A2AE20; -.
DR PeptideAtlas; A2AE20; -.
DR PRIDE; A2AE20; -.
DR ProteomicsDB; 291981; -.
DR Ensembl; ENSMUST00000040437; ENSMUSP00000048721; ENSMUSG00000037167.
DR GeneID; 278203; -.
DR KEGG; mmu:278203; -.
DR UCSC; uc009sul.2; mouse.
DR CTD; 389852; -.
DR MGI; MGI:2685564; Spaca5.
DR VEuPathDB; HostDB:ENSMUSG00000037167; -.
DR eggNOG; ENOG502SUHW; Eukaryota.
DR GeneTree; ENSGT00940000162205; -.
DR HOGENOM; CLU_111620_0_1_1; -.
DR InParanoid; A2AE20; -.
DR OMA; SAWWCNN; -.
DR OrthoDB; 1551203at2759; -.
DR PhylomeDB; A2AE20; -.
DR TreeFam; TF324882; -.
DR BioGRID-ORCS; 278203; 1 hit in 71 CRISPR screens.
DR PRO; PR:A2AE20; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2AE20; protein.
DR Bgee; ENSMUSG00000037167; Expressed in spermatid and 7 other tissues.
DR ExpressionAtlas; A2AE20; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR030064; LYZL5.
DR PANTHER; PTHR11407; PTHR11407; 1.
DR PANTHER; PTHR11407:SF31; PTHR11407:SF31; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; SSF53955; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..160
FT /note="Sperm acrosome-associated protein 5"
FT /id="PRO_0000284471"
FT DOMAIN 22..150
FT /note="C-type lysozyme"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT ACT_SITE 56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 27..147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 51..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 85..100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
FT DISULFID 96..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"
SQ SEQUENCE 160 AA; 18005 MW; 6B29416231FA5C1E CRC64;
MKVCSIVVVI LAVLLIAKLD AKIYERCELA KKLEEAGLDG FKGYTVGDWL CVAHYESGFD
TSFVDHNPDG SSEYGIFQLN SAWWCNNGIT PTQNLCNIDC NDLLNRHILD DIICAKRVAS
SHKSMKAWDS WTQHCAGHDL SEWLKGCSVR LKTDSSYNNW
