ID   LZ8_GANLU               Reviewed;         111 AA.
AC   P14945;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Immunomodulatory protein Ling Zhi-8;
DE            Short=LZ-8;
OS   Ganoderma lucidum (Ling zhi medicinal fungus) (Bracket fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Polyporaceae; Ganoderma.
OX   NCBI_TaxID=5315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1990000; DOI=10.1016/s0021-9258(18)52270-5;
RA   Murasugi A., Tanaka S., Komiyama N., Iwata N., Kino K., Tsunoo H.,
RA   Sakuma S.;
RT   "Molecular cloning of a cDNA and a gene encoding an immunomodulatory
RT   protein, Ling Zhi-8, from a fungus, Ganoderma lucidum.";
RL   J. Biol. Chem. 266:2486-2493(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-111, AND ACETYLATION AT SER-2.
RX   PubMed=2570780; DOI=10.1016/s0021-9258(19)84715-4;
RA   Tanaka S., Ko K., Kino K., Tsuchiya K., Yamashita A., Murasugi A.,
RA   Sakuma S., Tsunoo H.;
RT   "Complete amino acid sequence of an immunomodulatory protein, ling zhi-8
RT   (LZ-8). An immunomodulator from a fungus, Ganoderma lucidium, having
RT   similarity to immunoglobulin variable regions.";
RL   J. Biol. Chem. 264:16372-16377(1989).
CC   -!- SIMILARITY: Belongs to the fungal immunomodulatory protein (FIP)
CC       family. {ECO:0000305}.
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DR   EMBL; M58032; AAA33350.1; -; Genomic_DNA.
DR   PIR; A38618; JIMRZ8.
DR   PDB; 3F3H; X-ray; 2.10 A; A/B=1-111.
DR   PDBsum; 3F3H; -.
DR   AlphaFoldDB; P14945; -.
DR   SMR; P14945; -.
DR   iPTMnet; P14945; -.
DR   EvolutionaryTrace; P14945; -.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0002682; P:regulation of immune system process; IEA:InterPro.
DR   InterPro; IPR036344; FIP_sf.
DR   InterPro; IPR015339; Immunomodulatory_FIP-Fve_fun.
DR   Pfam; PF09259; Fve; 1.
DR   SUPFAM; SSF101542; SSF101542; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2570780"
FT   CHAIN           2..111
FT                   /note="Immunomodulatory protein Ling Zhi-8"
FT                   /id="PRO_0000084539"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:2570780"
FT   HELIX           3..14
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          15..20
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          24..27
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          33..41
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          49..54
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          57..62
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          73..76
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   HELIX           77..80
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   TURN            81..83
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          92..97
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   TURN            99..101
FT                   /evidence="ECO:0007829|PDB:3F3H"
FT   STRAND          104..110
FT                   /evidence="ECO:0007829|PDB:3F3H"
SQ   SEQUENCE   111 AA;  12510 MW;  294FB9D0F9EB73EB CRC64;
     MSDTALIFRL AWDVKKLSFD YTPNWGRGNP NNFIDTVTFP KVLTDKAYTY RVAVSGRNLG
     VKPSYAVESD GSQKVNFLEY NSGYGIADTN TIQVFVVDPD TNNDFIIAQW N