ID   LZIC_DANRE              Reviewed;         190 AA.
AC   Q6DHH7; Q4PS89;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Protein LZIC;
DE   AltName: Full=Leucine zipper and CTNNBIP1 domain-containing protein;
DE   AltName: Full=Leucine zipper and ICAT homologous domain-containing protein;
GN   Name=lzic; ORFNames=zgc:92310;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], LACK OF INTERACTION WITH CTNNB1, DEVELOPMENTAL
RP   STAGE, AND FUNCTION.
RX   PubMed=15932753; DOI=10.1016/j.ydbio.2005.04.026;
RA   Clements W.K., Kimelman D.;
RT   "LZIC regulates neuronal survival during zebrafish development.";
RL   Dev. Biol. 283:322-334(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for neuronal survival during early development.
CC       {ECO:0000269|PubMed:15932753}.
CC   -!- SUBUNIT: Does not interact with CTNNB1.
CC   -!- DEVELOPMENTAL STAGE: Expressed very early in development. Expression
CC       levels drop until shield stage and increase again during gastrulation
CC       and later development. Expressed abundantly in the developing brain,
CC       and at lower levels throughout the embryo.
CC       {ECO:0000269|PubMed:15932753}.
CC   -!- SIMILARITY: Belongs to the CTNNBIP1 family. {ECO:0000305}.
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DR   EMBL; DQ058007; AAY67864.1; -; mRNA.
DR   EMBL; BC075997; AAH75997.1; -; mRNA.
DR   RefSeq; NP_001002598.1; NM_001002598.1.
DR   AlphaFoldDB; Q6DHH7; -.
DR   SMR; Q6DHH7; -.
DR   STRING; 7955.ENSDARP00000072766; -.
DR   PaxDb; Q6DHH7; -.
DR   Ensembl; ENSDART00000078304; ENSDARP00000072766; ENSDARG00000055899.
DR   Ensembl; ENSDART00000193192; ENSDARP00000152932; ENSDARG00000055899.
DR   GeneID; 436871; -.
DR   KEGG; dre:436871; -.
DR   CTD; 84328; -.
DR   ZFIN; ZDB-GENE-040718-342; lzic.
DR   eggNOG; ENOG502QPUB; Eukaryota.
DR   GeneTree; ENSGT00940000159001; -.
DR   HOGENOM; CLU_091171_0_0_1; -.
DR   InParanoid; Q6DHH7; -.
DR   OMA; VIRMFAR; -.
DR   OrthoDB; 1483957at2759; -.
DR   PhylomeDB; Q6DHH7; -.
DR   TreeFam; TF314533; -.
DR   PRO; PR:Q6DHH7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000055899; Expressed in brain and 34 other tissues.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007417; P:central nervous system development; IMP:ZFIN.
DR   Gene3D; 1.10.10.490; -; 1.
DR   InterPro; IPR009428; ICAT_dom.
DR   InterPro; IPR036911; ICAT_sf.
DR   InterPro; IPR040065; LZIC.
DR   PANTHER; PTHR16505; PTHR16505; 1.
DR   Pfam; PF06384; ICAT; 1.
DR   SUPFAM; SSF81730; SSF81730; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Developmental protein; Differentiation; Neurogenesis;
KW   Reference proteome.
FT   CHAIN           1..190
FT                   /note="Protein LZIC"
FT                   /id="PRO_0000263695"
FT   COILED          6..64
FT                   /evidence="ECO:0000255"
FT   CONFLICT        58
FT                   /note="D -> E (in Ref. 1; AAY67864)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   190 AA;  21322 MW;  6F6BF832C53BC711 CRC64;
     MASRGKSETS KLRQNMEEQL DRLMQQLQDL EECREDLEEE EYEETKKETL EQLSEFNDSL
     KKLMSGNMTL VDELGGMQLA IQAAISQAFK TPEVIRLFAK KQPGQLRTRL AEMDRDVMVG
     KLSRDVFTQQ KVEILTALRK LGEKLTTEDE AFLAANASAT LSHFEKVTAS LGSEDKIMAL
     ASSGVGKTQT