LZIC_HUMAN
ID LZIC_HUMAN Reviewed; 190 AA.
AC Q8WZA0; B2R6F0; B4E2N0; Q96IU1;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Protein LZIC;
DE AltName: Full=Leucine zipper and CTNNBIP1 domain-containing protein;
DE AltName: Full=Leucine zipper and ICAT homologous domain-containing protein;
GN Name=LZIC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Stomach;
RX PubMed=11712074; DOI=10.3892/ijmm.8.6.611;
RA Katoh M.;
RT "Molecular cloning and characterization of LZIC, a novel gene encoding ICAT
RT homologous protein with leucine zipper domain.";
RL Int. J. Mol. Med. 8:611-615(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Tongue, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBUNIT: Does not interact with CTNNB1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8WZA0; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-5774346, EBI-1055254;
CC Q8WZA0; P55072: VCP; NbExp=3; IntAct=EBI-5774346, EBI-355164;
CC Q8WZA0; Q96NG5: ZNF558; NbExp=3; IntAct=EBI-5774346, EBI-373363;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WZA0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WZA0-2; Sequence=VSP_056083;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in
CC kidney. Up-regulated in several cases of gastric cancers.
CC {ECO:0000269|PubMed:11712074}.
CC -!- SIMILARITY: Belongs to the CTNNBIP1 family. {ECO:0000305}.
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DR EMBL; AB060688; BAB72100.1; -; mRNA.
DR EMBL; AK304348; BAG65192.1; -; mRNA.
DR EMBL; AK312550; BAG35447.1; -; mRNA.
DR EMBL; AL357140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471130; EAW71633.1; -; Genomic_DNA.
DR EMBL; BC007240; AAH07240.2; -; mRNA.
DR EMBL; BC063443; AAH63443.1; -; mRNA.
DR CCDS; CCDS107.1; -. [Q8WZA0-1]
DR RefSeq; NP_001303902.1; NM_001316973.1. [Q8WZA0-1]
DR RefSeq; NP_001303903.1; NM_001316974.1. [Q8WZA0-2]
DR RefSeq; NP_115744.2; NM_032368.4. [Q8WZA0-1]
DR AlphaFoldDB; Q8WZA0; -.
DR SMR; Q8WZA0; -.
DR BioGRID; 124052; 21.
DR IntAct; Q8WZA0; 17.
DR STRING; 9606.ENSP00000366430; -.
DR ChEMBL; CHEMBL4296296; -.
DR GlyGen; Q8WZA0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8WZA0; -.
DR PhosphoSitePlus; Q8WZA0; -.
DR BioMuta; LZIC; -.
DR DMDM; 74751644; -.
DR EPD; Q8WZA0; -.
DR jPOST; Q8WZA0; -.
DR MassIVE; Q8WZA0; -.
DR MaxQB; Q8WZA0; -.
DR PaxDb; Q8WZA0; -.
DR PeptideAtlas; Q8WZA0; -.
DR PRIDE; Q8WZA0; -.
DR ProteomicsDB; 5835; -.
DR ProteomicsDB; 75241; -. [Q8WZA0-1]
DR TopDownProteomics; Q8WZA0-1; -. [Q8WZA0-1]
DR Antibodypedia; 27776; 342 antibodies from 22 providers.
DR DNASU; 84328; -.
DR Ensembl; ENST00000377213.1; ENSP00000366418.1; ENSG00000162441.12. [Q8WZA0-1]
DR Ensembl; ENST00000377223.6; ENSP00000366430.1; ENSG00000162441.12. [Q8WZA0-1]
DR Ensembl; ENST00000400903.6; ENSP00000383695.2; ENSG00000162441.12. [Q8WZA0-1]
DR GeneID; 84328; -.
DR KEGG; hsa:84328; -.
DR MANE-Select; ENST00000377223.6; ENSP00000366430.1; NM_032368.5; NP_115744.2.
DR UCSC; uc001aqm.4; human. [Q8WZA0-1]
DR CTD; 84328; -.
DR DisGeNET; 84328; -.
DR GeneCards; LZIC; -.
DR HGNC; HGNC:17497; LZIC.
DR HPA; ENSG00000162441; Low tissue specificity.
DR MIM; 610458; gene.
DR neXtProt; NX_Q8WZA0; -.
DR OpenTargets; ENSG00000162441; -.
DR PharmGKB; PA30504; -.
DR VEuPathDB; HostDB:ENSG00000162441; -.
DR eggNOG; ENOG502QPUB; Eukaryota.
DR GeneTree; ENSGT00940000159001; -.
DR HOGENOM; CLU_091171_0_0_1; -.
DR InParanoid; Q8WZA0; -.
DR OMA; VIRMFAR; -.
DR OrthoDB; 1483957at2759; -.
DR PhylomeDB; Q8WZA0; -.
DR TreeFam; TF314533; -.
DR PathwayCommons; Q8WZA0; -.
DR SignaLink; Q8WZA0; -.
DR BioGRID-ORCS; 84328; 17 hits in 1081 CRISPR screens.
DR ChiTaRS; LZIC; human.
DR GenomeRNAi; 84328; -.
DR Pharos; Q8WZA0; Tdark.
DR PRO; PR:Q8WZA0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WZA0; protein.
DR Bgee; ENSG00000162441; Expressed in left testis and 186 other tissues.
DR ExpressionAtlas; Q8WZA0; baseline and differential.
DR Genevisible; Q8WZA0; HS.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR Gene3D; 1.10.10.490; -; 1.
DR InterPro; IPR009428; ICAT_dom.
DR InterPro; IPR036911; ICAT_sf.
DR InterPro; IPR040065; LZIC.
DR PANTHER; PTHR16505; PTHR16505; 1.
DR Pfam; PF06384; ICAT; 1.
DR SUPFAM; SSF81730; SSF81730; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..190
FT /note="Protein LZIC"
FT /id="PRO_0000263691"
FT COILED 2..63
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MNNFIFLKFMTLGTSRTGEIKM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056083"
FT VARIANT 104
FT /note="G -> D (in dbSNP:rs2304778)"
FT /id="VAR_053371"
SQ SEQUENCE 190 AA; 21495 MW; 2DDDD7B788F42DD8 CRC64;
MASRGKTETS KLKQNLEEQL DRLMQQLQDL EECREELDTD EYEETKKETL EQLSEFNDSL
KKIMSGNMTL VDELSGMQLA IQAAISQAFK TPEVIRLFAK KQPGQLRTRL AEMDRDLMVG
KLERDLYTQQ KVEILTALRK LGEKLTADDE AFLSANAGAI LSQFEKVSTD LGSGDKILAL
ASFEVEKTKK
