ID   LZIC_MOUSE              Reviewed;         190 AA.
AC   Q8K3C3; Q9D8V3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Protein LZIC;
DE   AltName: Full=Leucine zipper and CTNNBIP1 domain-containing protein;
DE   AltName: Full=Leucine zipper and ICAT homologous domain-containing protein;
GN   Name=Lzic;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND LACK OF INTERACTION WITH CTNNB1.
RC   TISSUE=Liver;
RX   PubMed=15932753; DOI=10.1016/j.ydbio.2005.04.026;
RA   Clements W.K., Kimelman D.;
RT   "LZIC regulates neuronal survival during zebrafish development.";
RL   Dev. Biol. 283:322-334(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Heart, and Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Does not interact with CTNNB1.
CC   -!- SIMILARITY: Belongs to the CTNNBIP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ058008; AAY67865.1; -; mRNA.
DR   EMBL; AK007657; BAB25167.2; -; mRNA.
DR   EMBL; AK146824; BAE27461.1; -; mRNA.
DR   EMBL; BC023174; AAH23174.1; -; mRNA.
DR   CCDS; CCDS18961.1; -.
DR   RefSeq; NP_081239.1; NM_026963.5.
DR   RefSeq; XP_006539216.1; XM_006539153.3.
DR   RefSeq; XP_017175871.1; XM_017320382.1.
DR   AlphaFoldDB; Q8K3C3; -.
DR   SMR; Q8K3C3; -.
DR   STRING; 10090.ENSMUSP00000030842; -.
DR   iPTMnet; Q8K3C3; -.
DR   PhosphoSitePlus; Q8K3C3; -.
DR   EPD; Q8K3C3; -.
DR   MaxQB; Q8K3C3; -.
DR   PaxDb; Q8K3C3; -.
DR   PeptideAtlas; Q8K3C3; -.
DR   PRIDE; Q8K3C3; -.
DR   ProteomicsDB; 292158; -.
DR   Antibodypedia; 27776; 342 antibodies from 22 providers.
DR   DNASU; 69151; -.
DR   Ensembl; ENSMUST00000030842; ENSMUSP00000030842; ENSMUSG00000028990.
DR   GeneID; 69151; -.
DR   KEGG; mmu:69151; -.
DR   UCSC; uc008vwl.1; mouse.
DR   CTD; 84328; -.
DR   MGI; MGI:1916401; Lzic.
DR   VEuPathDB; HostDB:ENSMUSG00000028990; -.
DR   eggNOG; ENOG502QPUB; Eukaryota.
DR   GeneTree; ENSGT00940000159001; -.
DR   HOGENOM; CLU_091171_0_0_1; -.
DR   InParanoid; Q8K3C3; -.
DR   OMA; VIRMFAR; -.
DR   OrthoDB; 1483957at2759; -.
DR   PhylomeDB; Q8K3C3; -.
DR   TreeFam; TF314533; -.
DR   BioGRID-ORCS; 69151; 3 hits in 71 CRISPR screens.
DR   ChiTaRS; Lzic; mouse.
DR   PRO; PR:Q8K3C3; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q8K3C3; protein.
DR   Bgee; ENSMUSG00000028990; Expressed in manus and 211 other tissues.
DR   ExpressionAtlas; Q8K3C3; baseline and differential.
DR   Genevisible; Q8K3C3; MM.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR   Gene3D; 1.10.10.490; -; 1.
DR   InterPro; IPR009428; ICAT_dom.
DR   InterPro; IPR036911; ICAT_sf.
DR   InterPro; IPR040065; LZIC.
DR   PANTHER; PTHR16505; PTHR16505; 1.
DR   Pfam; PF06384; ICAT; 1.
DR   SUPFAM; SSF81730; SSF81730; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..190
FT                   /note="Protein LZIC"
FT                   /id="PRO_0000263692"
FT   COILED          2..63
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   190 AA;  21537 MW;  2E4F8BF7CE8554CD CRC64;
     MASRGKTETS KLKQNLEEQL DRLMQQLQDL EECREELDAD EYEETKKETL EQLSEFNDSL
     KKIMSGNMTL VDELSGMQLA IQAAISQAFK TPEVIRLFAK KQPGQLRTRL AEMDRDLMVG
     KLERELYTQR KVEILTALRK LGEKLTEDDE TFLSANASAV LSQFEKVSTE LGSGDKVLAL
     AGFDVEKAKK