ID   LZTL1_BOVIN             Reviewed;         299 AA.
AC   Q3ZBL4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Leucine zipper transcription factor-like protein 1;
GN   Name=LZTFL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates ciliary localization of the BBSome complex.
CC       Together with the BBSome complex, controls SMO ciliary trafficking and
CC       contributes to the sonic hedgehog (SHH) pathway regulation. May play a
CC       role in neurite outgrowth. May have tumor suppressor function (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with BBS9; the interaction mediates
CC       the association of LZTL1 with the BBsome complex and regulates BBSome
CC       ciliary trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LZTFL1 family. {ECO:0000305}.
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DR   EMBL; BT030520; ABQ12960.1; -; mRNA.
DR   EMBL; BC103231; AAI03232.1; -; mRNA.
DR   RefSeq; NP_001029597.1; NM_001034425.1.
DR   AlphaFoldDB; Q3ZBL4; -.
DR   SMR; Q3ZBL4; -.
DR   STRING; 9913.ENSBTAP00000001942; -.
DR   PaxDb; Q3ZBL4; -.
DR   PeptideAtlas; Q3ZBL4; -.
DR   PRIDE; Q3ZBL4; -.
DR   Ensembl; ENSBTAT00000001942; ENSBTAP00000001942; ENSBTAG00000001484.
DR   GeneID; 512570; -.
DR   KEGG; bta:512570; -.
DR   CTD; 54585; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001484; -.
DR   VGNC; VGNC:31119; LZTFL1.
DR   eggNOG; ENOG502QRGB; Eukaryota.
DR   GeneTree; ENSGT00390000016415; -.
DR   HOGENOM; CLU_083519_1_0_1; -.
DR   InParanoid; Q3ZBL4; -.
DR   OMA; LAKYETE; -.
DR   OrthoDB; 1107668at2759; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000001484; Expressed in spermatid and 111 other tissues.
DR   GO; GO:0005929; C:cilium; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0002177; C:manchette; IEA:Ensembl.
DR   GO; GO:0062063; F:BBSome binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:1903568; P:negative regulation of protein localization to ciliary membrane; IEA:Ensembl.
DR   GO; GO:1903565; P:negative regulation of protein localization to cilium; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   InterPro; IPR026157; LZTFL1.
DR   PANTHER; PTHR21635; PTHR21635; 1.
DR   Pfam; PF15294; Leu_zip; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Leucine zipper transcription factor-like protein 1"
FT                   /id="PRO_0000318758"
FT   REGION          145..299
FT                   /note="Interaction with BSS9"
FT                   /evidence="ECO:0000250"
FT   COILED          96..296
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  34577 MW;  7BBDE61330227554 CRC64;
     MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEETFT VDEVSEVLNG
     LQAVVHSEVE SELINTAYTN VLLLRQLFSQ AEKWYLKLQT DISELENREL LEQVAEFEKA
     EFTSSNKKSI IDSMKPKLAP LHEGGAAELL NKEIIRLQEE NEKLKSRLKT IESQATDALD
     EKSKLERALQ DLQLEHGSQK DFIKAQDLSD LENTVAALKS EFQKTLNDQT ENQKSLEENL
     ATAKHDLLRV QEQLSMAEKE LEKKFQQTAA FRNMKEILTK KNDQIKDLRK RLAKYEPED