ID   LZTL1_MACFA             Reviewed;         299 AA.
AC   Q4R6V9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Leucine zipper transcription factor-like protein 1;
GN   Name=LZTFL1; ORFNames=QtsA-17016;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-299.
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates ciliary localization of the BBSome complex.
CC       Together with the BBSome complex, controls SMO ciliary trafficking and
CC       contributes to the sonic hedgehog (SHH) pathway regulation. May play a
CC       role in neurite outgrowth. May have tumor suppressor function (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with BBS9; the interaction mediates
CC       the association of LZTL1 with the BBsome complex and regulates BBSome
CC       ciliary trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LZTFL1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE01165.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB169071; BAE01165.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001272105.1; NM_001285176.1.
DR   AlphaFoldDB; Q4R6V9; -.
DR   SMR; Q4R6V9; -.
DR   STRING; 9541.XP_005546941.1; -.
DR   GeneID; 101925603; -.
DR   CTD; 54585; -.
DR   eggNOG; ENOG502QRGB; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026157; LZTFL1.
DR   PANTHER; PTHR21635; PTHR21635; 1.
DR   Pfam; PF15294; Leu_zip; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Leucine zipper transcription factor-like protein 1"
FT                   /id="PRO_0000318759"
FT   REGION          145..299
FT                   /note="Interaction with BSS9"
FT                   /evidence="ECO:0000250"
FT   COILED          88..296
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  34623 MW;  F90D520CA523EFE8 CRC64;
     MAELGLNEHH QNEYINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEETFT IDEVSEVLNG
     LQAVVHSEVE SELINTAYTN VLLLRQLLAQ AEKWYLKLQT DISELENREL LEQVAEFEKA
     EITSSNKKPI LDITKPKLAP LNEGGTAELL NKEILRLQEE NEKLKSRLKT IEIQATSALD
     EKSKLEKALQ DLQLDQGNQK DFIKAQDLSN LENTVAALKS EFQKTLNDKT ENQKSLEENL
     ATAKHDLLRV QEQLHMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAQYEPED