ID   LZTL1_PONAB             Reviewed;         299 AA.
AC   Q5RBR4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Leucine zipper transcription factor-like protein 1;
GN   Name=LZTFL1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates ciliary localization of the BBSome complex.
CC       Together with the BBSome complex, controls SMO ciliary trafficking and
CC       contributes to the sonic hedgehog (SHH) pathway regulation. May play a
CC       role in neurite outgrowth. May have tumor suppressor function (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with BBS9; the interaction mediates
CC       the association of LZTL1 with the BBsome complex and regulates BBSome
CC       ciliary trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LZTFL1 family. {ECO:0000305}.
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DR   EMBL; CR858573; CAH90796.1; -; mRNA.
DR   RefSeq; NP_001127335.1; NM_001133863.2.
DR   AlphaFoldDB; Q5RBR4; -.
DR   SMR; Q5RBR4; -.
DR   STRING; 9601.ENSPPYP00000015594; -.
DR   Ensembl; ENSPPYT00000016215; ENSPPYP00000015594; ENSPPYG00000013942.
DR   GeneID; 100174397; -.
DR   KEGG; pon:100174397; -.
DR   CTD; 54585; -.
DR   eggNOG; ENOG502QRGB; Eukaryota.
DR   GeneTree; ENSGT00390000016415; -.
DR   HOGENOM; CLU_083519_0_0_1; -.
DR   InParanoid; Q5RBR4; -.
DR   OMA; LAKYETE; -.
DR   OrthoDB; 1107668at2759; -.
DR   TreeFam; TF329023; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026157; LZTFL1.
DR   PANTHER; PTHR21635; PTHR21635; 1.
DR   Pfam; PF15294; Leu_zip; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Leucine zipper transcription factor-like protein 1"
FT                   /id="PRO_0000318761"
FT   REGION          145..299
FT                   /note="Interaction with BSS9"
FT                   /evidence="ECO:0000250"
FT   COILED          96..296
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  34592 MW;  D60B4B3B98A83E1A CRC64;
     MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEETFT IDEVSEVLNG
     LQAVVHSEVE SELINTAYTN VLLLRQLFAQ AEKWYLKLQT DISELENREL LEQVAEFEKA
     EITSSNKKPI LDVTKPKLAP LNEGGTAELL NKEILRLQEE NEKLKSRLKT VEIQATNALD
     EKSKLEKALQ DLQLDQGNQK DFIKAQDLSN LENTVAALKS EFQKTLNDKT ENQKSLEENL
     ATAKHDLLRV QEQLHMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAQYEPED