ID   LZTL1_RAT               Reviewed;         299 AA.
AC   Q562C6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Leucine zipper transcription factor-like protein 1;
GN   Name=Lztfl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates ciliary localization of the BBSome complex.
CC       Together with the BBSome complex, controls SMO ciliary trafficking and
CC       contributes to the sonic hedgehog (SHH) pathway regulation. May play a
CC       role in neurite outgrowth. May have tumor suppressor function (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Interacts with BBS9; the interaction mediates
CC       the association of LZTL1 with the BBsome complex and regulates BBSome
CC       ciliary trafficking (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LZTFL1 family. {ECO:0000305}.
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DR   EMBL; BC092585; AAH92585.1; -; mRNA.
DR   RefSeq; NP_001019437.1; NM_001024266.1.
DR   RefSeq; XP_006244253.1; XM_006244191.1.
DR   AlphaFoldDB; Q562C6; -.
DR   SMR; Q562C6; -.
DR   STRING; 10116.ENSRNOP00000008254; -.
DR   iPTMnet; Q562C6; -.
DR   PhosphoSitePlus; Q562C6; -.
DR   PaxDb; Q562C6; -.
DR   PRIDE; Q562C6; -.
DR   Ensembl; ENSRNOT00000091431; ENSRNOP00000071325; ENSRNOG00000006244.
DR   GeneID; 316102; -.
DR   KEGG; rno:316102; -.
DR   UCSC; RGD:1306628; rat.
DR   CTD; 54585; -.
DR   RGD; 1306628; Lztfl1.
DR   eggNOG; ENOG502QRGB; Eukaryota.
DR   GeneTree; ENSGT00390000016415; -.
DR   HOGENOM; CLU_083519_0_0_1; -.
DR   InParanoid; Q562C6; -.
DR   OMA; LAKYETE; -.
DR   OrthoDB; 1107668at2759; -.
DR   PhylomeDB; Q562C6; -.
DR   TreeFam; TF329023; -.
DR   Reactome; R-RNO-5620922; BBSome-mediated cargo-targeting to cilium.
DR   PRO; PR:Q562C6; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000006244; Expressed in testis and 20 other tissues.
DR   Genevisible; Q562C6; RN.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0002177; C:manchette; ISO:RGD.
DR   GO; GO:0062063; F:BBSome binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR   GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR   GO; GO:1903568; P:negative regulation of protein localization to ciliary membrane; ISO:RGD.
DR   GO; GO:1903565; P:negative regulation of protein localization to cilium; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   InterPro; IPR026157; LZTFL1.
DR   PANTHER; PTHR21635; PTHR21635; 1.
DR   Pfam; PF15294; Leu_zip; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Leucine zipper transcription factor-like protein 1"
FT                   /id="PRO_0000318762"
FT   REGION          145..299
FT                   /note="Interaction with BSS9"
FT                   /evidence="ECO:0000250"
FT   COILED          145..299
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  34638 MW;  282E5A663C92F413 CRC64;
     MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEETFT IDEVSEVLNG
     LQAVVHSEVE SELINTAHTN VLLLRQLFSQ AEKWYLKLQT DVSELENREL LEQVAEFEKA
     EFASSNKKPI IDITKPKLVP INEGGTTELL NKEILRLQQE NEKLKSRLKT IETQAVNALD
     EKSKLERVLQ DLQLDQGNQQ DFIKAQDLDD LENTVAALKS EFQKTLNDKT ENQKSLEENL
     AAAKHDLLRV QEQLSMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAKYESED