LZTS1_HUMAN
ID LZTS1_HUMAN Reviewed; 596 AA.
AC Q9Y250; D3DSQ6; Q9Y5V7; Q9Y5V8; Q9Y5V9; Q9Y5W0; Q9Y5W1; Q9Y5W2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Leucine zipper putative tumor suppressor 1;
DE AltName: Full=F37/esophageal cancer-related gene-coding leucine-zipper motif;
DE AltName: Full=Fez1;
GN Name=LZTS1; Synonyms=FEZ1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7),
RP INVOLVEMENT IN ESCR, VARIANTS PRO-29 AND GLU-119, FUNCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=10097140; DOI=10.1073/pnas.96.7.3928;
RA Ishii H., Baffa R., Numata S., Murakumo Y., Rattan S., Inoue H., Mori M.,
RA Fidanza V., Alder H., Croce C.M.;
RT "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its
RT expression is altered in multiple human tumors.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:3928-3933(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND ALTERNATIVE SPLICING.
RX PubMed=11464283; DOI=10.1038/sj.onc.1204539;
RA Cabeza-Arvelaiz Y., Sepulveda J.L., Lebovitz R.M., Thompson T.C.,
RA Chinault A.C.;
RT "Functional identification of LZTS1 as a candidate prostate tumor
RT suppressor gene on human chromosome 8p22.";
RL Oncogene 20:4169-4179(2001).
RN [5]
RP FUNCTION, PHOSPHORYLATION, SUBCELLULAR LOCATION, AND INTERACTION WITH EEF1G
RP AND CDK1.
RX PubMed=11504921; DOI=10.1073/pnas.181222898;
RA Ishii H., Vecchione A., Murakumo Y., Baldassarre G., Numata S.,
RA Trapasso F., Alder H., Baffa R., Croce C.M.;
RT "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates
RT mitosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:10374-10379(2001).
RN [6]
RP INTERACTION WITH TLK2.
RX PubMed=16484223; DOI=10.1074/jbc.m513280200;
RA Assmann E.M., Alborghetti M.R., Camargo M.E.R., Kobarg J.;
RT "FEZ1 dimerization and interaction with transcription regulatory proteins
RT involves its coiled-coil region.";
RL J. Biol. Chem. 281:9869-9881(2006).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- FUNCTION: Involved in the regulation of cell growth. May stabilize the
CC active CDC2-cyclin B1 complex and thereby contribute to the regulation
CC of the cell cycle and the prevention of uncontrolled cell
CC proliferation. May act as a tumor suppressor.
CC {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283,
CC ECO:0000269|PubMed:11504921}.
CC -!- SUBUNIT: Binds EEF1G, TLK2 and CDK1.
CC -!- INTERACTION:
CC Q9Y250; A2BDD9: AMOT; NbExp=3; IntAct=EBI-1216080, EBI-17286414;
CC Q9Y250; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-1216080, EBI-541426;
CC Q9Y250; Q13895: BYSL; NbExp=3; IntAct=EBI-1216080, EBI-358049;
CC Q9Y250; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-1216080, EBI-11530605;
CC Q9Y250; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-1216080, EBI-10171570;
CC Q9Y250; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-1216080, EBI-744556;
CC Q9Y250; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-1216080, EBI-10961312;
CC Q9Y250; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-1216080, EBI-10961624;
CC Q9Y250; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-1216080, EBI-10175300;
CC Q9Y250; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-1216080, EBI-396137;
CC Q9Y250; P30307: CDC25C; NbExp=2; IntAct=EBI-1216080, EBI-974439;
CC Q9Y250; Q16543: CDC37; NbExp=3; IntAct=EBI-1216080, EBI-295634;
CC Q9Y250; O00311: CDC7; NbExp=3; IntAct=EBI-1216080, EBI-374980;
CC Q9Y250; Q9Y592-2: CEP83; NbExp=3; IntAct=EBI-1216080, EBI-11123098;
CC Q9Y250; P61024: CKS1B; NbExp=3; IntAct=EBI-1216080, EBI-456371;
CC Q9Y250; Q14746: COG2; NbExp=3; IntAct=EBI-1216080, EBI-389449;
CC Q9Y250; P53618: COPB1; NbExp=3; IntAct=EBI-1216080, EBI-359063;
CC Q9Y250; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-1216080, EBI-5453285;
CC Q9Y250; P26196: DDX6; NbExp=3; IntAct=EBI-1216080, EBI-351257;
CC Q9Y250; Q14241: ELOA; NbExp=3; IntAct=EBI-1216080, EBI-742350;
CC Q9Y250; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-1216080, EBI-744099;
CC Q9Y250; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-1216080, EBI-742102;
CC Q9Y250; Q3B820: FAM161A; NbExp=5; IntAct=EBI-1216080, EBI-719941;
CC Q9Y250; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-1216080, EBI-7225287;
CC Q9Y250; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-1216080, EBI-742802;
CC Q9Y250; Q96KD3-2: FAM71F1; NbExp=3; IntAct=EBI-1216080, EBI-6448805;
CC Q9Y250; Q96LP2: FAM81B; NbExp=3; IntAct=EBI-1216080, EBI-10290827;
CC Q9Y250; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-1216080, EBI-6658203;
CC Q9Y250; O95995: GAS8; NbExp=3; IntAct=EBI-1216080, EBI-1052570;
CC Q9Y250; Q92805: GOLGA1; NbExp=3; IntAct=EBI-1216080, EBI-6164177;
CC Q9Y250; Q92917: GPKOW; NbExp=3; IntAct=EBI-1216080, EBI-746309;
CC Q9Y250; Q6ZQW0-2: IDO2; NbExp=3; IntAct=EBI-1216080, EBI-12233645;
CC Q9Y250; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-1216080, EBI-2556193;
CC Q9Y250; Q92993: KAT5; NbExp=3; IntAct=EBI-1216080, EBI-399080;
CC Q9Y250; Q674X7-2: KAZN; NbExp=3; IntAct=EBI-1216080, EBI-12024294;
CC Q9Y250; O60341: KDM1A; NbExp=3; IntAct=EBI-1216080, EBI-710124;
CC Q9Y250; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-1216080, EBI-8472129;
CC Q9Y250; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1216080, EBI-14069005;
CC Q9Y250; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-1216080, EBI-726510;
CC Q9Y250; Q03252: LMNB2; NbExp=3; IntAct=EBI-1216080, EBI-2830427;
CC Q9Y250; P25800: LMO1; NbExp=3; IntAct=EBI-1216080, EBI-8639312;
CC Q9Y250; P25791-3: LMO2; NbExp=3; IntAct=EBI-1216080, EBI-11959475;
CC Q9Y250; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-1216080, EBI-11742507;
CC Q9Y250; P61968: LMO4; NbExp=3; IntAct=EBI-1216080, EBI-2798728;
CC Q9Y250; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-1216080, EBI-739832;
CC Q9Y250; Q9Y333: LSM2; NbExp=3; IntAct=EBI-1216080, EBI-347416;
CC Q9Y250; P45984: MAPK9; NbExp=3; IntAct=EBI-1216080, EBI-713568;
CC Q9Y250; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-1216080, EBI-348259;
CC Q9Y250; Q8WXB1: METTL21A; NbExp=3; IntAct=EBI-1216080, EBI-8652459;
CC Q9Y250; P55081: MFAP1; NbExp=3; IntAct=EBI-1216080, EBI-1048159;
CC Q9Y250; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-1216080, EBI-14086479;
CC Q9Y250; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-1216080, EBI-10172526;
CC Q9Y250; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-1216080, EBI-11750983;
CC Q9Y250; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-1216080, EBI-741158;
CC Q9Y250; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-1216080, EBI-14066006;
CC Q9Y250; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-1216080, EBI-79165;
CC Q9Y250; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-1216080, EBI-12069346;
CC Q9Y250; O15160: POLR1C; NbExp=3; IntAct=EBI-1216080, EBI-1055079;
CC Q9Y250; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-1216080, EBI-5452779;
CC Q9Y250; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-1216080, EBI-2557469;
CC Q9Y250; O43741: PRKAB2; NbExp=3; IntAct=EBI-1216080, EBI-1053424;
CC Q9Y250; Q99633: PRPF18; NbExp=3; IntAct=EBI-1216080, EBI-2798416;
CC Q9Y250; O43395: PRPF3; NbExp=3; IntAct=EBI-1216080, EBI-744322;
CC Q9Y250; P25786: PSMA1; NbExp=3; IntAct=EBI-1216080, EBI-359352;
CC Q9Y250; Q8WXF1-2: PSPC1; NbExp=3; IntAct=EBI-1216080, EBI-12135327;
CC Q9Y250; P47897: QARS1; NbExp=3; IntAct=EBI-1216080, EBI-347462;
CC Q9Y250; P47224: RABIF; NbExp=3; IntAct=EBI-1216080, EBI-713992;
CC Q9Y250; Q8TCX5: RHPN1; NbExp=3; IntAct=EBI-1216080, EBI-746325;
CC Q9Y250; Q9UHP6: RSPH14; NbExp=3; IntAct=EBI-1216080, EBI-748350;
CC Q9Y250; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-1216080, EBI-11984663;
CC Q9Y250; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-1216080, EBI-748391;
CC Q9Y250; Q96ES7: SGF29; NbExp=3; IntAct=EBI-1216080, EBI-743117;
CC Q9Y250; O94964-4: SOGA1; NbExp=3; IntAct=EBI-1216080, EBI-14083835;
CC Q9Y250; Q5MJ68: SPDYC; NbExp=3; IntAct=EBI-1216080, EBI-12162209;
CC Q9Y250; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-1216080, EBI-740595;
CC Q9Y250; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-1216080, EBI-745392;
CC Q9Y250; Q5T7P8-2: SYT6; NbExp=3; IntAct=EBI-1216080, EBI-10246152;
CC Q9Y250; Q96C24: SYTL4; NbExp=3; IntAct=EBI-1216080, EBI-747142;
CC Q9Y250; Q86TI0: TBC1D1; NbExp=3; IntAct=EBI-1216080, EBI-1644036;
CC Q9Y250; Q9P0N9: TBC1D7; NbExp=3; IntAct=EBI-1216080, EBI-3258000;
CC Q9Y250; Q15560: TCEA2; NbExp=3; IntAct=EBI-1216080, EBI-710310;
CC Q9Y250; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-1216080, EBI-744794;
CC Q9Y250; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-1216080, EBI-10241197;
CC Q9Y250; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-1216080, EBI-2851213;
CC Q9Y250; P40222: TXLNA; NbExp=3; IntAct=EBI-1216080, EBI-359793;
CC Q9Y250; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-1216080, EBI-6116822;
CC Q9Y250; O14530: TXNDC9; NbExp=3; IntAct=EBI-1216080, EBI-707554;
CC Q9Y250; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-1216080, EBI-7353612;
CC Q9Y250; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-1216080, EBI-10183064;
CC Q9Y250; Q96E35: ZMYND19; NbExp=3; IntAct=EBI-1216080, EBI-746595;
CC Q9Y250; P15622-3: ZNF250; NbExp=3; IntAct=EBI-1216080, EBI-10177272;
CC Q9Y250; P17036: ZNF3; NbExp=3; IntAct=EBI-1216080, EBI-1640965;
CC Q9Y250; P13682: ZNF35; NbExp=3; IntAct=EBI-1216080, EBI-11041653;
CC Q9Y250; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-1216080, EBI-740727;
CC Q9Y250; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-1216080, EBI-10172590;
CC Q9Y250; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-1216080, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}.
CC Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}.
CC Note=Associated with the plasma membrane and with microtubules.
CC Detected in dendritic spines, especially in the postsynaptic density
CC (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q9Y250-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y250-2; Sequence=VSP_009946;
CC Name=3;
CC IsoId=Q9Y250-3; Sequence=VSP_009945;
CC Name=4;
CC IsoId=Q9Y250-4; Sequence=VSP_009944;
CC Name=5;
CC IsoId=Q9Y250-5; Sequence=VSP_009943;
CC Name=6;
CC IsoId=Q9Y250-6; Sequence=VSP_009942;
CC Name=7;
CC IsoId=Q9Y250-7; Sequence=VSP_009940, VSP_009941;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis, prostate, spleen,
CC thymus, ovary and brain. Detected at lower levels in heart, placenta,
CC small intestine, colon, liver, kidney, skeletal muscle and pancreas.
CC Not detectable in primary tumors from breast and prostate and in many
CC cancer cell lines. {ECO:0000269|PubMed:10097140}.
CC -!- PTM: Phosphorylated on serine residues. Hyperphosphorylated by the
CC cAMP-dependent kinase PKA during cell-cycle progression.
CC -!- DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the
CC esophagus. The most common types are esophageal squamous cell carcinoma
CC and adenocarcinoma. Cancer of the esophagus remains a devastating
CC disease because it is usually not detected until it has progressed to
CC an advanced incurable stage. {ECO:0000269|PubMed:10097140}. Note=The
CC disease may be caused by variants affecting the gene represented in
CC this entry.
CC -!- MISCELLANEOUS: Defects in LZTS1 are found in many types of tumors.
CC -!- SIMILARITY: Belongs to the LZTS family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/LZTS1ID367ch8p21.html";
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DR EMBL; AF123652; AAD23833.1; -; mRNA.
DR EMBL; AF123653; AAD23834.1; -; Genomic_DNA.
DR EMBL; AF123654; AAD23835.1; -; mRNA.
DR EMBL; AF123655; AAD23836.1; -; mRNA.
DR EMBL; AF123656; AAD23837.1; -; mRNA.
DR EMBL; AF123657; AAD23838.1; -; mRNA.
DR EMBL; AF123658; AAD23839.1; -; mRNA.
DR EMBL; AF123659; AAD23840.1; -; mRNA.
DR EMBL; CH471080; EAW63753.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63755.1; -; Genomic_DNA.
DR EMBL; BC075006; AAH75006.1; -; mRNA.
DR EMBL; BC075007; AAH75007.1; -; mRNA.
DR CCDS; CCDS6015.1; -. [Q9Y250-1]
DR RefSeq; NP_066300.1; NM_021020.3. [Q9Y250-1]
DR RefSeq; XP_005273451.1; XM_005273394.3.
DR RefSeq; XP_011542685.1; XM_011544383.2.
DR RefSeq; XP_011542686.1; XM_011544384.2. [Q9Y250-1]
DR RefSeq; XP_011542687.1; XM_011544385.2. [Q9Y250-1]
DR RefSeq; XP_011542688.1; XM_011544386.2. [Q9Y250-1]
DR AlphaFoldDB; Q9Y250; -.
DR SMR; Q9Y250; -.
DR BioGRID; 116348; 125.
DR IntAct; Q9Y250; 101.
DR MINT; Q9Y250; -.
DR STRING; 9606.ENSP00000370981; -.
DR iPTMnet; Q9Y250; -.
DR PhosphoSitePlus; Q9Y250; -.
DR BioMuta; LZTS1; -.
DR DMDM; 46396556; -.
DR EPD; Q9Y250; -.
DR jPOST; Q9Y250; -.
DR MassIVE; Q9Y250; -.
DR MaxQB; Q9Y250; -.
DR PaxDb; Q9Y250; -.
DR PeptideAtlas; Q9Y250; -.
DR PRIDE; Q9Y250; -.
DR ProteomicsDB; 85646; -. [Q9Y250-1]
DR ProteomicsDB; 85647; -. [Q9Y250-2]
DR ProteomicsDB; 85648; -. [Q9Y250-3]
DR ProteomicsDB; 85649; -. [Q9Y250-4]
DR ProteomicsDB; 85650; -. [Q9Y250-5]
DR ProteomicsDB; 85651; -. [Q9Y250-6]
DR ProteomicsDB; 85652; -. [Q9Y250-7]
DR Antibodypedia; 1747; 249 antibodies from 27 providers.
DR DNASU; 11178; -.
DR Ensembl; ENST00000265801.6; ENSP00000265801.6; ENSG00000061337.15. [Q9Y250-1]
DR Ensembl; ENST00000381569.5; ENSP00000370981.1; ENSG00000061337.15. [Q9Y250-1]
DR Ensembl; ENST00000522290.5; ENSP00000429263.1; ENSG00000061337.15. [Q9Y250-4]
DR Ensembl; ENST00000616228.1; ENSP00000479534.1; ENSG00000061337.15. [Q9Y250-7]
DR GeneID; 11178; -.
DR KEGG; hsa:11178; -.
DR MANE-Select; ENST00000381569.5; ENSP00000370981.1; NM_021020.5; NP_066300.1.
DR UCSC; uc003wzr.3; human. [Q9Y250-1]
DR CTD; 11178; -.
DR DisGeNET; 11178; -.
DR GeneCards; LZTS1; -.
DR HGNC; HGNC:13861; LZTS1.
DR HPA; ENSG00000061337; Group enriched (brain, parathyroid gland).
DR MalaCards; LZTS1; -.
DR MIM; 133239; phenotype.
DR MIM; 606551; gene.
DR neXtProt; NX_Q9Y250; -.
DR OpenTargets; ENSG00000061337; -.
DR PharmGKB; PA30507; -.
DR VEuPathDB; HostDB:ENSG00000061337; -.
DR eggNOG; ENOG502QRU7; Eukaryota.
DR GeneTree; ENSGT00940000154078; -.
DR HOGENOM; CLU_026379_2_1_1; -.
DR InParanoid; Q9Y250; -.
DR OMA; LEPKCNS; -.
DR OrthoDB; 1014871at2759; -.
DR PhylomeDB; Q9Y250; -.
DR TreeFam; TF331420; -.
DR PathwayCommons; Q9Y250; -.
DR SignaLink; Q9Y250; -.
DR BioGRID-ORCS; 11178; 10 hits in 1073 CRISPR screens.
DR GeneWiki; LZTS1; -.
DR GenomeRNAi; 11178; -.
DR Pharos; Q9Y250; Tbio.
DR PRO; PR:Q9Y250; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9Y250; protein.
DR Bgee; ENSG00000061337; Expressed in cortical plate and 132 other tissues.
DR Genevisible; Q9Y250; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IEA:InterPro.
DR GO; GO:0016242; P:negative regulation of macroautophagy; IMP:BHF-UCL.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IBA:GO_Central.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IBA:GO_Central.
DR InterPro; IPR045329; LZTS.
DR InterPro; IPR033293; LZTS1.
DR PANTHER; PTHR19354; PTHR19354; 1.
DR PANTHER; PTHR19354:SF5; PTHR19354:SF5; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell membrane; Cell projection;
KW Coiled coil; Cytoplasm; Lipoprotein; Membrane; Myristate; Phosphoprotein;
KW Reference proteome; Synapse; Tumor suppressor.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..596
FT /note="Leucine zipper putative tumor suppressor 1"
FT /id="PRO_0000182971"
FT REGION 136..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 256..374
FT /evidence="ECO:0000255"
FT COMPBIAS 171..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 55..76
FT /note="SSSKMGKSEDFFYIKVSQKARG -> AMTRCPRASSMSGSCGRRRRRR (in
FT isoform 7)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009940"
FT VAR_SEQ 77..596
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009941"
FT VAR_SEQ 186..571
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009942"
FT VAR_SEQ 454..545
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009943"
FT VAR_SEQ 468..526
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009944"
FT VAR_SEQ 471..503
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009945"
FT VAR_SEQ 505..527
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10097140"
FT /id="VSP_009946"
FT VARIANT 29
FT /note="S -> P (found in an esophageal cancer sample;
FT esophageal squamous cell carcinoma; somatic mutation;
FT dbSNP:rs28937897)"
FT /evidence="ECO:0000269|PubMed:10097140"
FT /id="VAR_018274"
FT VARIANT 50
FT /note="S -> F (in dbSNP:rs34620053)"
FT /id="VAR_053490"
FT VARIANT 119
FT /note="K -> E (found in an esophageal cancer sample;
FT esophageal squamous cell carcinoma; somatic mutation;
FT dbSNP:rs119473032)"
FT /evidence="ECO:0000269|PubMed:10097140"
FT /id="VAR_018275"
FT VARIANT 475
FT /note="L -> V (in dbSNP:rs723874)"
FT /id="VAR_018276"
SQ SEQUENCE 596 AA; 66613 MW; 8ED96C707BA27659 CRC64;
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG
KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG
AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG
HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR
RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE
TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK
DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA
QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI
QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI
