LZTS1_RAT
ID LZTS1_RAT Reviewed; 601 AA.
AC Q8CFC9;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Leucine zipper putative tumor suppressor 1;
DE AltName: Full=PSD-Zip70;
GN Name=Lzts1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], MYRISTOYLATION AT GLY-2, TISSUE SPECIFICITY,
RP AND SUBCELLULAR LOCATION.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=12415013; DOI=10.1242/jcs.00127;
RA Konno D., Ko J.-A., Usui S., Hori K., Maruoka H., Inui M., Fujikado T.,
RA Tano Y., Suzuki T., Tohyama K., Sobue K.;
RT "The postsynaptic density and dendritic raft localization of PSD-Zip70,
RT which contains an N-myristoylation sequence and leucine-zipper motifs.";
RL J. Cell Sci. 115:4695-4706(2002).
CC -!- FUNCTION: Involved in the regulation of cell growth. May stabilize the
CC active CDC2-cyclin B1 complex and thereby contribute to the regulation
CC of the cell cycle and the prevention of uncontrolled cell
CC proliferation. May act as tumor suppressor (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds EEF1G, TLK2 and CDK1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12415013}. Cell
CC membrane {ECO:0000250}. Cell projection, dendritic spine
CC {ECO:0000269|PubMed:12415013}. Postsynaptic density
CC {ECO:0000269|PubMed:12415013}. Synapse {ECO:0000269|PubMed:12415013}.
CC Note=Associated with the plasma membrane and with microtubules (By
CC similarity). Detected in dendritic spines, especially in the
CC postsynaptic density. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, in particular in cortex,
CC the CA2 region of the hippocampus, olfactory bulb, striatum and pons.
CC Not detectable in the other tissues tested.
CC {ECO:0000269|PubMed:12415013}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in cerebellum in 1 to 3 week old
CC rats. Expression levels before and after are much lower. Expression in
CC total brain increases slightly during development and remains at a
CC constant high level after birth.
CC -!- PTM: Phosphorylated on serine residues. Hyperphosphorylated by the
CC cAMP-dependent kinase PKA during cell-cycle progression (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LZTS family. {ECO:0000305}.
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DR EMBL; AB075607; BAC16535.1; -; mRNA.
DR RefSeq; NP_703200.1; NM_153470.1.
DR AlphaFoldDB; Q8CFC9; -.
DR SMR; Q8CFC9; -.
DR STRING; 10116.ENSRNOP00000015800; -.
DR iPTMnet; Q8CFC9; -.
DR PhosphoSitePlus; Q8CFC9; -.
DR PaxDb; Q8CFC9; -.
DR PRIDE; Q8CFC9; -.
DR Ensembl; ENSRNOT00000015799; ENSRNOP00000015800; ENSRNOG00000011826.
DR GeneID; 266711; -.
DR KEGG; rno:266711; -.
DR UCSC; RGD:708565; rat.
DR CTD; 11178; -.
DR RGD; 708565; Lzts1.
DR eggNOG; ENOG502QRU7; Eukaryota.
DR GeneTree; ENSGT00940000154078; -.
DR HOGENOM; CLU_026379_2_1_1; -.
DR InParanoid; Q8CFC9; -.
DR OMA; LEPKCNS; -.
DR OrthoDB; 1014871at2759; -.
DR PhylomeDB; Q8CFC9; -.
DR TreeFam; TF331420; -.
DR PRO; PR:Q8CFC9; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000011826; Expressed in frontal cortex and 17 other tissues.
DR Genevisible; Q8CFC9; RN.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR GO; GO:0044297; C:cell body; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043198; C:dendritic shaft; IDA:RGD.
DR GO; GO:0043197; C:dendritic spine; IDA:RGD.
DR GO; GO:0043005; C:neuron projection; IDA:RGD.
DR GO; GO:0014069; C:postsynaptic density; IDA:RGD.
DR GO; GO:0045211; C:postsynaptic membrane; IDA:RGD.
DR GO; GO:0045202; C:synapse; IDA:RGD.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IEA:InterPro.
DR GO; GO:0016242; P:negative regulation of macroautophagy; ISO:RGD.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IMP:RGD.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IMP:RGD.
DR InterPro; IPR045329; LZTS.
DR InterPro; IPR033293; LZTS1.
DR PANTHER; PTHR19354; PTHR19354; 1.
DR PANTHER; PTHR19354:SF5; PTHR19354:SF5; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell membrane; Cell projection; Coiled coil; Cytoplasm;
KW Lipoprotein; Membrane; Myristate; Reference proteome; Synapse;
KW Tumor suppressor.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..601
FT /note="Leucine zipper putative tumor suppressor 1"
FT /id="PRO_0000182973"
FT REGION 135..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 255..573
FT /evidence="ECO:0000255"
FT COMPBIAS 171..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:12415013"
SQ SEQUENCE 601 AA; 67565 MW; A7FC7DF8541714CF CRC64;
MGSVSSLISG HSLHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GRGKSSSKMG
KSEDFFYIKV SQKARGSHRP DYTALSSGDM GGQTGVDFDP ATPPKLMPFS SQLEMSSDKA
AVRPTAFKPV LPRSGAILHS SPESTNHQLH PMPPDKPKEQ ELKPGLCSGA LSDSGRNSMS
SLPTHSTTSS YQLDPLVTPV GPTSRFGGSA HNITQGIILQ DSNMMSLKAL SFSDGGSKLA
HPGKVEKGSS CVRSPLSTDE CTIQELEQKL LQRETALQKL QRSFDEKEFA SGQTFEERPR
RTRDELECLE PKSKLKPASQ KSQRTQQVLQ LQVLQLQQEK RQLRQELESL MKEQDLLETK
LRSYEREKTN FAPALEETQW EVCQKSGEIS LLKQQLKESQ MEVNAKASEI LSLKAQLKDT
RGKLEGMELK TQDLESALRT KGLELEVCEN ELQRKKNEAE LLREKVNLLE QELLELRAQA
ALHRDAAPLG PPGIGLTFSE DIPALQRELD RLRAELKEER QGHDQMSSGF QHERLVWKEE
KEKVIQYQKQ LQQSYLAMYQ RNQRLEKALQ QLARGDIAGE PFEIDLEGAD IPYEDIIATE
I
