LZTS2_HUMAN
ID LZTS2_HUMAN Reviewed; 669 AA.
AC Q9BRK4; B1AL14; D3DR72; Q8N3I0; Q96J79; Q96JL2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026};
DE Short=hLZTS2;
DE AltName: Full=Protein LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026};
GN Name=LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026};
GN Synonyms=KIAA1813, LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-669, ALTERNATIVE SPLICING, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Prostate;
RX PubMed=11709705; DOI=10.1038/sj.onc.1204866;
RA Cabeza-Arvelaiz Y., Thompson T.C., Sepulveda J.L., Chinault A.C.;
RT "LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.";
RL Oncogene 20:6707-6717(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-669.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, NUCLEAR EXPORT
RP SIGNAL, AND MUTAGENESIS OF LEU-638 AND LEU-640.
RX PubMed=17000760; DOI=10.1128/mcb.01031-06;
RA Thyssen G., Li T.-H., Lehmann L., Zhuo M., Sharma M., Sun Z.;
RT "LZTS2 is a novel beta-catenin-interacting protein and regulates the
RT nuclear export of beta-catenin.";
RL Mol. Cell. Biol. 26:8857-8867(2006).
RN [8]
RP FUNCTION, INTERACTION WITH GAMMA-TUBULIN; KIF23 AND KATNB1, AND SUBCELLULAR
RP LOCATION.
RX PubMed=17351128; DOI=10.1096/fj.06-7254com;
RA Sudo H., Maru Y.;
RT "LAPSER1 is a putative cytokinetic tumor suppressor that shows the same
RT centrosome and midbody subcellular localization pattern as p80 katanin.";
RL FASEB J. 21:2086-2100(2007).
RN [9]
RP FUNCTION, AND INDUCTION.
RX PubMed=17950943; DOI=10.1016/j.bbamcr.2007.08.005;
RA Cho H.H., Joo H.J., Song J.S., Bae Y.C., Jung J.S.;
RT "Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by
RT lzts2 in human adipose tissue-derived mesenchymal stem cells.";
RL Biochim. Biophys. Acta 1783:419-428(2008).
RN [10]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18490357; DOI=10.1093/hmg/ddn153;
RA Sudo H., Maru Y.;
RT "LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of
RT katanin-mediated microtubule severing.";
RL Hum. Mol. Genet. 17:2524-2540(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP VARIANTS [LARGE SCALE ANALYSIS] HIS-121 AND ARG-291.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC and release from the centrosome. Required for central spindle formation
CC and the completion of cytokinesis. May negatively regulate axonal
CC outgrowth by preventing the formation of microtubule bundles that are
CC necessary for transport within the elongating axon. Negative regulator
CC of the Wnt signaling pathway. Represses beta-catenin-mediated
CC transcriptional activation by promoting the nuclear exclusion of beta-
CC catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760,
CC ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943,
CC ECO:0000269|PubMed:18490357}.
CC -!- SUBUNIT: Interacts with KATNB1. Also interacts with CTNNB1, gamma-
CC tubulin and KIF23. {ECO:0000255|HAMAP-Rule:MF_03026,
CC ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128}.
CC -!- INTERACTION:
CC Q9BRK4; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-741037, EBI-11096309;
CC Q9BRK4; Q9ULW3: ABT1; NbExp=3; IntAct=EBI-741037, EBI-2602396;
CC Q9BRK4; Q8WTP8: AEN; NbExp=3; IntAct=EBI-741037, EBI-8637627;
CC Q9BRK4; Q8WTP8-2: AEN; NbExp=3; IntAct=EBI-741037, EBI-12119298;
CC Q9BRK4; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-741037, EBI-744859;
CC Q9BRK4; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-741037, EBI-541426;
CC Q9BRK4; A7KAX9: ARHGAP32; NbExp=3; IntAct=EBI-741037, EBI-308663;
CC Q9BRK4; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-741037, EBI-742909;
CC Q9BRK4; Q8N5M1: ATPAF2; NbExp=6; IntAct=EBI-741037, EBI-1166928;
CC Q9BRK4; Q8TBE0: BAHD1; NbExp=7; IntAct=EBI-741037, EBI-742750;
CC Q9BRK4; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-741037, EBI-745073;
CC Q9BRK4; P21810: BGN; NbExp=4; IntAct=EBI-741037, EBI-762076;
CC Q9BRK4; Q13895: BYSL; NbExp=6; IntAct=EBI-741037, EBI-358049;
CC Q9BRK4; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-741037, EBI-8643161;
CC Q9BRK4; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-741037, EBI-739879;
CC Q9BRK4; Q9H7E9: C8orf33; NbExp=3; IntAct=EBI-741037, EBI-715389;
CC Q9BRK4; Q9NP86: CABP5; NbExp=3; IntAct=EBI-741037, EBI-10311131;
CC Q9BRK4; Q9H257: CARD9; NbExp=3; IntAct=EBI-741037, EBI-751319;
CC Q9BRK4; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-741037, EBI-744545;
CC Q9BRK4; Q9HC52: CBX8; NbExp=6; IntAct=EBI-741037, EBI-712912;
CC Q9BRK4; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-741037, EBI-10238351;
CC Q9BRK4; P24863: CCNC; NbExp=3; IntAct=EBI-741037, EBI-395261;
CC Q9BRK4; P51959: CCNG1; NbExp=3; IntAct=EBI-741037, EBI-3905829;
CC Q9BRK4; O75909: CCNK; NbExp=3; IntAct=EBI-741037, EBI-739806;
CC Q9BRK4; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-741037, EBI-396137;
CC Q9BRK4; Q07002: CDK18; NbExp=3; IntAct=EBI-741037, EBI-746238;
CC Q9BRK4; Q8IVW4: CDKL3; NbExp=3; IntAct=EBI-741037, EBI-3919850;
CC Q9BRK4; P38936: CDKN1A; NbExp=3; IntAct=EBI-741037, EBI-375077;
CC Q9BRK4; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-741037, EBI-1104570;
CC Q9BRK4; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-741037, EBI-10181988;
CC Q9BRK4; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-741037, EBI-749051;
CC Q9BRK4; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-741037, EBI-743375;
CC Q9BRK4; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-741037, EBI-741528;
CC Q9BRK4; Q8N3C7: CLIP4; NbExp=3; IntAct=EBI-741037, EBI-5655540;
CC Q9BRK4; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-741037, EBI-741032;
CC Q9BRK4; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-741037, EBI-10269984;
CC Q9BRK4; P48730: CSNK1D; NbExp=3; IntAct=EBI-741037, EBI-751621;
CC Q9BRK4; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-741037, EBI-5453285;
CC Q9BRK4; Q96GG9: DCUN1D1; NbExp=6; IntAct=EBI-741037, EBI-740086;
CC Q9BRK4; Q9BY27: DGCR6L; NbExp=3; IntAct=EBI-741037, EBI-742953;
CC Q9BRK4; O14645: DNALI1; NbExp=3; IntAct=EBI-741037, EBI-395638;
CC Q9BRK4; Q13115: DUSP4; NbExp=3; IntAct=EBI-741037, EBI-6591081;
CC Q9BRK4; Q13627: DYRK1A; NbExp=4; IntAct=EBI-741037, EBI-1053596;
CC Q9BRK4; Q9Y463: DYRK1B; NbExp=4; IntAct=EBI-741037, EBI-634187;
CC Q9BRK4; Q92630: DYRK2; NbExp=3; IntAct=EBI-741037, EBI-749432;
CC Q9BRK4; Q08426: EHHADH; NbExp=3; IntAct=EBI-741037, EBI-2339219;
CC Q9BRK4; O15371: EIF3D; NbExp=3; IntAct=EBI-741037, EBI-353818;
CC Q9BRK4; O60573: EIF4E2; NbExp=3; IntAct=EBI-741037, EBI-398610;
CC Q9BRK4; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-741037, EBI-371876;
CC Q9BRK4; O95990-3: FAM107A; NbExp=3; IntAct=EBI-741037, EBI-10192902;
CC Q9BRK4; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-741037, EBI-741626;
CC Q9BRK4; Q3B820: FAM161A; NbExp=6; IntAct=EBI-741037, EBI-719941;
CC Q9BRK4; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-741037, EBI-745689;
CC Q9BRK4; A6H8Z2: FAM221B; NbExp=3; IntAct=EBI-741037, EBI-12006844;
CC Q9BRK4; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-741037, EBI-742802;
CC Q9BRK4; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-741037, EBI-10247271;
CC Q9BRK4; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-741037, EBI-6658203;
CC Q9BRK4; Q9NW38: FANCL; NbExp=3; IntAct=EBI-741037, EBI-2339898;
CC Q9BRK4; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-741037, EBI-10244131;
CC Q9BRK4; Q96JP0: FEM1C; NbExp=3; IntAct=EBI-741037, EBI-2515330;
CC Q9BRK4; P61328: FGF12; NbExp=3; IntAct=EBI-741037, EBI-6657662;
CC Q9BRK4; O75344: FKBP6; NbExp=7; IntAct=EBI-741037, EBI-744771;
CC Q9BRK4; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-741037, EBI-744935;
CC Q9BRK4; Q14331: FRG1; NbExp=3; IntAct=EBI-741037, EBI-2515248;
CC Q9BRK4; Q96NE9: FRMD6; NbExp=3; IntAct=EBI-741037, EBI-741729;
CC Q9BRK4; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-741037, EBI-372506;
CC Q9BRK4; P15976-2: GATA1; NbExp=3; IntAct=EBI-741037, EBI-9090198;
CC Q9BRK4; Q96CN9: GCC1; NbExp=3; IntAct=EBI-741037, EBI-746252;
CC Q9BRK4; P55040: GEM; NbExp=6; IntAct=EBI-741037, EBI-744104;
CC Q9BRK4; Q8TF65: GIPC2; NbExp=3; IntAct=EBI-741037, EBI-712067;
CC Q9BRK4; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-741037, EBI-748515;
CC Q9BRK4; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-741037, EBI-745707;
CC Q9BRK4; Q9NVN8: GNL3L; NbExp=3; IntAct=EBI-741037, EBI-746682;
CC Q9BRK4; O95872: GPANK1; NbExp=4; IntAct=EBI-741037, EBI-751540;
CC Q9BRK4; Q9NWQ4: GPATCH2L; NbExp=3; IntAct=EBI-741037, EBI-5666657;
CC Q9BRK4; P62993: GRB2; NbExp=3; IntAct=EBI-741037, EBI-401755;
CC Q9BRK4; Q8TCT9: HM13; NbExp=3; IntAct=EBI-741037, EBI-347472;
CC Q9BRK4; Q9NSB8: HOMER2; NbExp=3; IntAct=EBI-741037, EBI-2126733;
CC Q9BRK4; P17482: HOXB9; NbExp=4; IntAct=EBI-741037, EBI-745290;
CC Q9BRK4; P10809: HSPD1; NbExp=7; IntAct=EBI-741037, EBI-352528;
CC Q9BRK4; Q9UMF0: ICAM5; NbExp=3; IntAct=EBI-741037, EBI-6398041;
CC Q9BRK4; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-741037, EBI-11955401;
CC Q9BRK4; Q9C086: INO80B; NbExp=3; IntAct=EBI-741037, EBI-715611;
CC Q9BRK4; Q9H0B3: IQCN; NbExp=3; IntAct=EBI-741037, EBI-745878;
CC Q9BRK4; Q92993: KAT5; NbExp=6; IntAct=EBI-741037, EBI-399080;
CC Q9BRK4; Q674X7: KAZN; NbExp=3; IntAct=EBI-741037, EBI-949239;
CC Q9BRK4; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-741037, EBI-2125614;
CC Q9BRK4; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-741037, EBI-14069005;
CC Q9BRK4; O14901: KLF11; NbExp=3; IntAct=EBI-741037, EBI-948266;
CC Q9BRK4; P52292: KPNA2; NbExp=3; IntAct=EBI-741037, EBI-349938;
CC Q9BRK4; Q14847: LASP1; NbExp=3; IntAct=EBI-741037, EBI-742828;
CC Q9BRK4; P06239: LCK; NbExp=3; IntAct=EBI-741037, EBI-1348;
CC Q9BRK4; Q96GY3: LIN37; NbExp=3; IntAct=EBI-741037, EBI-748884;
CC Q9BRK4; P25800: LMO1; NbExp=3; IntAct=EBI-741037, EBI-8639312;
CC Q9BRK4; P25791: LMO2; NbExp=3; IntAct=EBI-741037, EBI-739696;
CC Q9BRK4; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-741037, EBI-11742507;
CC Q9BRK4; Q8N8X9: MAB21L3; NbExp=6; IntAct=EBI-741037, EBI-10268010;
CC Q9BRK4; O15481: MAGEB4; NbExp=3; IntAct=EBI-741037, EBI-751857;
CC Q9BRK4; P28482: MAPK1; NbExp=4; IntAct=EBI-741037, EBI-959949;
CC Q9BRK4; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-741037, EBI-1104564;
CC Q9BRK4; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-741037, EBI-14086479;
CC Q9BRK4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-741037, EBI-10172526;
CC Q9BRK4; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-741037, EBI-399246;
CC Q9BRK4; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-741037, EBI-10288852;
CC Q9BRK4; Q15014: MORF4L2; NbExp=3; IntAct=EBI-741037, EBI-399257;
CC Q9BRK4; Q6PF18: MORN3; NbExp=3; IntAct=EBI-741037, EBI-9675802;
CC Q9BRK4; P00540: MOS; NbExp=3; IntAct=EBI-741037, EBI-1757866;
CC Q9BRK4; Q13330: MTA1; NbExp=3; IntAct=EBI-741037, EBI-714236;
CC Q9BRK4; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-741037, EBI-744402;
CC Q9BRK4; P52298: NCBP2; NbExp=3; IntAct=EBI-741037, EBI-464729;
CC Q9BRK4; O43639: NCK2; NbExp=6; IntAct=EBI-741037, EBI-713635;
CC Q9BRK4; O76041: NEBL; NbExp=3; IntAct=EBI-741037, EBI-2880203;
CC Q9BRK4; Q9HC98: NEK6; NbExp=3; IntAct=EBI-741037, EBI-740364;
CC Q9BRK4; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-741037, EBI-11750983;
CC Q9BRK4; Q9Y221: NIP7; NbExp=3; IntAct=EBI-741037, EBI-749003;
CC Q9BRK4; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-741037, EBI-741158;
CC Q9BRK4; Q96DC9: OTUB2; NbExp=3; IntAct=EBI-741037, EBI-746259;
CC Q9BRK4; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-741037, EBI-11022007;
CC Q9BRK4; O43189: PHF1; NbExp=3; IntAct=EBI-741037, EBI-530034;
CC Q9BRK4; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-741037, EBI-2339674;
CC Q9BRK4; Q99569: PKP4; NbExp=3; IntAct=EBI-741037, EBI-726447;
CC Q9BRK4; Q494U1: PLEKHN1; NbExp=3; IntAct=EBI-741037, EBI-10241513;
CC Q9BRK4; Q8WUT1: POLDIP3; NbExp=6; IntAct=EBI-741037, EBI-10276663;
CC Q9BRK4; O15160: POLR1C; NbExp=3; IntAct=EBI-741037, EBI-1055079;
CC Q9BRK4; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-741037, EBI-2557469;
CC Q9BRK4; O60828: PQBP1; NbExp=6; IntAct=EBI-741037, EBI-713867;
CC Q9BRK4; P54646: PRKAA2; NbExp=3; IntAct=EBI-741037, EBI-1383852;
CC Q9BRK4; O43741: PRKAB2; NbExp=4; IntAct=EBI-741037, EBI-1053424;
CC Q9BRK4; Q99633: PRPF18; NbExp=3; IntAct=EBI-741037, EBI-2798416;
CC Q9BRK4; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-741037, EBI-1567797;
CC Q9BRK4; P0CG20: PRR35; NbExp=3; IntAct=EBI-741037, EBI-11986293;
CC Q9BRK4; P25786: PSMA1; NbExp=3; IntAct=EBI-741037, EBI-359352;
CC Q9BRK4; P47897: QARS1; NbExp=6; IntAct=EBI-741037, EBI-347462;
CC Q9BRK4; P47897-2: QARS1; NbExp=3; IntAct=EBI-741037, EBI-10209725;
CC Q9BRK4; P63000: RAC1; NbExp=3; IntAct=EBI-741037, EBI-413628;
CC Q9BRK4; O75771: RAD51D; NbExp=9; IntAct=EBI-741037, EBI-1055693;
CC Q9BRK4; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-741037, EBI-744023;
CC Q9BRK4; Q96T37: RBM15; NbExp=3; IntAct=EBI-741037, EBI-2514922;
CC Q9BRK4; Q96IZ5: RBM41; NbExp=3; IntAct=EBI-741037, EBI-740773;
CC Q9BRK4; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-741037, EBI-743428;
CC Q9BRK4; Q9BSD3: RHNO1; NbExp=3; IntAct=EBI-741037, EBI-9658624;
CC Q9BRK4; Q13671: RIN1; NbExp=9; IntAct=EBI-741037, EBI-366017;
CC Q9BRK4; Q9H4P4: RNF41; NbExp=3; IntAct=EBI-741037, EBI-2130266;
CC Q9BRK4; Q14D33: RTP5; NbExp=3; IntAct=EBI-741037, EBI-10217913;
CC Q9BRK4; Q06455-4: RUNX1T1; NbExp=3; IntAct=EBI-741037, EBI-10224192;
CC Q9BRK4; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-741037, EBI-748391;
CC Q9BRK4; Q6NXQ0: SFRS2; NbExp=3; IntAct=EBI-741037, EBI-10251550;
CC Q9BRK4; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-741037, EBI-747035;
CC Q9BRK4; Q96B97: SH3KBP1; NbExp=3; IntAct=EBI-741037, EBI-346595;
CC Q9BRK4; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-741037, EBI-10225873;
CC Q9BRK4; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-741037, EBI-10313866;
CC Q9BRK4; Q05CH4: SLC15A3; NbExp=3; IntAct=EBI-741037, EBI-10223741;
CC Q9BRK4; P12236: SLC25A6; NbExp=3; IntAct=EBI-741037, EBI-356254;
CC Q9BRK4; Q15043-2: SLC39A14; NbExp=3; IntAct=EBI-741037, EBI-12176399;
CC Q9BRK4; O95391: SLU7; NbExp=3; IntAct=EBI-741037, EBI-750559;
CC Q9BRK4; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-741037, EBI-358489;
CC Q9BRK4; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-741037, EBI-741850;
CC Q9BRK4; Q13573: SNW1; NbExp=3; IntAct=EBI-741037, EBI-632715;
CC Q9BRK4; Q8N9S9: SNX31; NbExp=3; IntAct=EBI-741037, EBI-9380649;
CC Q9BRK4; Q9UM82: SPATA2; NbExp=3; IntAct=EBI-741037, EBI-744066;
CC Q9BRK4; Q86W54: SPATA24; NbExp=3; IntAct=EBI-741037, EBI-3916986;
CC Q9BRK4; Q9H0A9: SPATC1L; NbExp=3; IntAct=EBI-741037, EBI-372911;
CC Q9BRK4; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-741037, EBI-717201;
CC Q9BRK4; Q8WUK8: STAC; NbExp=3; IntAct=EBI-741037, EBI-10276615;
CC Q9BRK4; Q99469: STAC; NbExp=3; IntAct=EBI-741037, EBI-2652799;
CC Q9BRK4; Q8IYB8: SUPV3L1; NbExp=3; IntAct=EBI-741037, EBI-2876787;
CC Q9BRK4; O43463: SUV39H1; NbExp=6; IntAct=EBI-741037, EBI-349968;
CC Q9BRK4; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-741037, EBI-745392;
CC Q9BRK4; Q9P0N9: TBC1D7; NbExp=3; IntAct=EBI-741037, EBI-3258000;
CC Q9BRK4; Q15560: TCEA2; NbExp=3; IntAct=EBI-741037, EBI-710310;
CC Q9BRK4; Q9BT92: TCHP; NbExp=3; IntAct=EBI-741037, EBI-740781;
CC Q9BRK4; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-741037, EBI-10176734;
CC Q9BRK4; Q15561: TEAD4; NbExp=3; IntAct=EBI-741037, EBI-747736;
CC Q9BRK4; Q9P2Z0: THAP10; NbExp=3; IntAct=EBI-741037, EBI-745404;
CC Q9BRK4; Q9BT49: THAP7; NbExp=6; IntAct=EBI-741037, EBI-741350;
CC Q9BRK4; Q08117-2: TLE5; NbExp=3; IntAct=EBI-741037, EBI-11741437;
CC Q9BRK4; Q96KP6: TNIP3; NbExp=6; IntAct=EBI-741037, EBI-2509913;
CC Q9BRK4; Q14134: TRIM29; NbExp=4; IntAct=EBI-741037, EBI-702370;
CC Q9BRK4; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-741037, EBI-5235829;
CC Q9BRK4; Q99598: TSNAX; NbExp=3; IntAct=EBI-741037, EBI-742638;
CC Q9BRK4; Q96PF2: TSSK2; NbExp=3; IntAct=EBI-741037, EBI-852089;
CC Q9BRK4; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-741037, EBI-3918381;
CC Q9BRK4; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-741037, EBI-6447954;
CC Q9BRK4; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-741037, EBI-9090990;
CC Q9BRK4; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-741037, EBI-11979997;
CC Q9BRK4; P83876: TXNL4A; NbExp=3; IntAct=EBI-741037, EBI-746539;
CC Q9BRK4; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-741037, EBI-7353612;
CC Q9BRK4; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-741037, EBI-1380492;
CC Q9BRK4; Q15853: USF2; NbExp=3; IntAct=EBI-741037, EBI-1055994;
CC Q9BRK4; O75604: USP2; NbExp=6; IntAct=EBI-741037, EBI-743272;
CC Q9BRK4; Q08E77: UTP14C; NbExp=4; IntAct=EBI-741037, EBI-10225961;
CC Q9BRK4; Q14119: VEZF1; NbExp=3; IntAct=EBI-741037, EBI-11980193;
CC Q9BRK4; Q06250: WT1-AS; NbExp=3; IntAct=EBI-741037, EBI-10223946;
CC Q9BRK4; P24278: ZBTB25; NbExp=3; IntAct=EBI-741037, EBI-739899;
CC Q9BRK4; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-741037, EBI-14104088;
CC Q9BRK4; A0A0S2Z6H0: ZGPAT; NbExp=4; IntAct=EBI-741037, EBI-16428984;
CC Q9BRK4; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-741037, EBI-3439227;
CC Q9BRK4; Q8N5A5-2: ZGPAT; NbExp=9; IntAct=EBI-741037, EBI-10183064;
CC Q9BRK4; Q9BRR0: ZKSCAN3; NbExp=3; IntAct=EBI-741037, EBI-1965777;
CC Q9BRK4; Q96NC0: ZMAT2; NbExp=3; IntAct=EBI-741037, EBI-2682299;
CC Q9BRK4; Q96E35: ZMYND19; NbExp=4; IntAct=EBI-741037, EBI-746595;
CC Q9BRK4; Q15973: ZNF124; NbExp=3; IntAct=EBI-741037, EBI-2555767;
CC Q9BRK4; P17024: ZNF20; NbExp=3; IntAct=EBI-741037, EBI-717634;
CC Q9BRK4; P15622-3: ZNF250; NbExp=3; IntAct=EBI-741037, EBI-10177272;
CC Q9BRK4; Q9H9D4: ZNF408; NbExp=4; IntAct=EBI-741037, EBI-347633;
CC Q9BRK4; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-741037, EBI-740727;
CC Q9BRK4; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-741037, EBI-743265;
CC Q9BRK4; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-741037, EBI-740232;
CC Q9BRK4; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-741037, EBI-1105370;
CC Q9BRK4; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-741037, EBI-10172590;
CC Q9BRK4; Q9P0T4: ZNF581; NbExp=4; IntAct=EBI-741037, EBI-745520;
CC Q9BRK4; Q5T619: ZNF648; NbExp=3; IntAct=EBI-741037, EBI-11985915;
CC Q9BRK4; A8K932; NbExp=3; IntAct=EBI-741037, EBI-10174671;
CC Q9BRK4; Q95HA4; NbExp=3; IntAct=EBI-741037, EBI-10236795;
CC Q9BRK4; Q9H6F0; NbExp=3; IntAct=EBI-741037, EBI-10307481;
CC Q9BRK4; P03410: tax; Xeno; NbExp=5; IntAct=EBI-741037, EBI-9676218;
CC Q9BRK4; P0C206; Xeno; NbExp=4; IntAct=EBI-741037, EBI-9675596;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome. Note=Localized to the centrosome
CC throughout the cell cycle. Localized to the midbody in cells undergoing
CC cytokinesis.
CC -!- TISSUE SPECIFICITY: Highly expressed in prostate and testis, and at
CC slightly lower levels in spleen, thymus, uterus, small intestine and
CC colon. {ECO:0000269|PubMed:11709705}.
CC -!- INDUCTION: By inhibition of NF-kappa-B signaling.
CC {ECO:0000269|PubMed:17950943}.
CC -!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000255|HAMAP-
CC Rule:MF_03026}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47442.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB058716; BAB47442.1; ALT_INIT; mRNA.
DR EMBL; AL133215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49790.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49791.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49792.1; -; Genomic_DNA.
DR EMBL; BC006212; AAH06212.2; -; mRNA.
DR EMBL; BC058938; AAH58938.1; -; mRNA.
DR EMBL; AY029201; AAK31577.1; -; mRNA.
DR EMBL; AL834338; CAD39005.1; -; mRNA.
DR CCDS; CCDS7507.1; -.
DR RefSeq; NP_001305028.1; NM_001318099.1.
DR RefSeq; NP_001305029.1; NM_001318100.1.
DR RefSeq; NP_001305030.1; NM_001318101.1.
DR RefSeq; NP_115805.1; NM_032429.3.
DR RefSeq; XP_005270279.1; XM_005270222.4.
DR RefSeq; XP_016872269.1; XM_017016780.1.
DR AlphaFoldDB; Q9BRK4; -.
DR SMR; Q9BRK4; -.
DR BioGRID; 124083; 508.
DR IntAct; Q9BRK4; 325.
DR MINT; Q9BRK4; -.
DR STRING; 9606.ENSP00000359240; -.
DR GlyGen; Q9BRK4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BRK4; -.
DR PhosphoSitePlus; Q9BRK4; -.
DR BioMuta; LZTS2; -.
DR DMDM; 46396501; -.
DR EPD; Q9BRK4; -.
DR jPOST; Q9BRK4; -.
DR MassIVE; Q9BRK4; -.
DR MaxQB; Q9BRK4; -.
DR PaxDb; Q9BRK4; -.
DR PeptideAtlas; Q9BRK4; -.
DR PRIDE; Q9BRK4; -.
DR ProteomicsDB; 78778; -.
DR Antibodypedia; 31240; 157 antibodies from 27 providers.
DR DNASU; 84445; -.
DR Ensembl; ENST00000370220.1; ENSP00000359240.1; ENSG00000107816.17.
DR Ensembl; ENST00000370223.7; ENSP00000359243.3; ENSG00000107816.17.
DR GeneID; 84445; -.
DR KEGG; hsa:84445; -.
DR UCSC; uc001ksj.4; human.
DR CTD; 84445; -.
DR DisGeNET; 84445; -.
DR GeneCards; LZTS2; -.
DR HGNC; HGNC:29381; LZTS2.
DR HPA; ENSG00000107816; Low tissue specificity.
DR MIM; 610454; gene.
DR neXtProt; NX_Q9BRK4; -.
DR OpenTargets; ENSG00000107816; -.
DR PharmGKB; PA134944540; -.
DR VEuPathDB; HostDB:ENSG00000107816; -.
DR eggNOG; ENOG502QWFS; Eukaryota.
DR GeneTree; ENSGT00940000154078; -.
DR HOGENOM; CLU_026379_2_0_1; -.
DR InParanoid; Q9BRK4; -.
DR OMA; EDCTAQA; -.
DR OrthoDB; 1014871at2759; -.
DR PhylomeDB; Q9BRK4; -.
DR TreeFam; TF331420; -.
DR PathwayCommons; Q9BRK4; -.
DR SignaLink; Q9BRK4; -.
DR BioGRID-ORCS; 84445; 12 hits in 1083 CRISPR screens.
DR ChiTaRS; LZTS2; human.
DR GenomeRNAi; 84445; -.
DR Pharos; Q9BRK4; Tbio.
DR PRO; PR:Q9BRK4; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q9BRK4; protein.
DR Bgee; ENSG00000107816; Expressed in mucosa of stomach and 167 other tissues.
DR ExpressionAtlas; Q9BRK4; baseline and differential.
DR Genevisible; Q9BRK4; HS.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-UniRule.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0031982; C:vesicle; IDA:BHF-UCL.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0051168; P:nuclear export; IEA:UniProtKB-UniRule.
DR GO; GO:0051255; P:spindle midzone assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR HAMAP; MF_03026; LZTS2; 1.
DR InterPro; IPR045329; LZTS.
DR InterPro; IPR028597; LZTS2.
DR PANTHER; PTHR19354; PTHR19354; 1.
DR PANTHER; PTHR19354:SF4; PTHR19354:SF4; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Phosphoprotein; Reference proteome;
KW Wnt signaling pathway.
FT CHAIN 1..669
FT /note="Leucine zipper putative tumor suppressor 2"
FT /id="PRO_0000182974"
FT REGION 1..332
FT /note="Required for centrosomal localization"
FT /evidence="ECO:0000250"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..669
FT /note="Sufficient for interaction with CTNNB1"
FT /evidence="ECO:0000269|PubMed:17000760"
FT REGION 450..669
FT /note="Sufficient for interaction with KATNB1 and for
FT inhibition of katanin-mediated microtubule severing"
FT /evidence="ECO:0000250"
FT COILED 328..649
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03026"
FT MOTIF 631..640
FT /note="Nuclear export signal"
FT COMPBIAS 105..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 249
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91YU6"
FT MOD_RES 296
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q91YU6"
FT MOD_RES 570
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT VARIANT 121
FT /note="R -> H (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs367898512)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036364"
FT VARIANT 291
FT /note="G -> R (in a breast cancer sample; somatic mutation;
FT dbSNP:rs1235690743)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036365"
FT VARIANT 299
FT /note="R -> W (in dbSNP:rs2275381)"
FT /id="VAR_018277"
FT MUTAGEN 638
FT /note="L->A: Induces nuclear accumulation. Impairs nuclear
FT exclusion of beta-catenin; when associated with A-640."
FT /evidence="ECO:0000269|PubMed:17000760"
FT MUTAGEN 640
FT /note="L->A: Induces nuclear accumulation. Impairs nuclear
FT exclusion of beta-catenin; when associated with A-38."
FT /evidence="ECO:0000269|PubMed:17000760"
FT CONFLICT 289
FT /note="V -> L (in Ref. 4; AAH58938)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 669 AA; 72759 MW; 1274FD9A36A217E6 CRC64;
MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP PGPTFFRQQD
GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP PSPSSDVEDA REQRAHNAHL
RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT
QLFGGPASSS SSSSSSSAAD KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT
SSPGGHLPSH GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA
SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN EATMCQAYEE
RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE KRQLQDDFAQ LLQEREQLER
RCATLEREQR ELGPRLEETK WEVCQKSGEI SLLKQQLKES QAELVQKGSE LVALRVALRE
ARATLRVSEG RARGLQEAAR ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP
PVPPATADPF LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER
LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL GLAEQAPCIC
LEEITATEI
