ID   LZTS2_XENLA             Reviewed;         666 AA.
AC   Q5U4W1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Leucine zipper putative tumor suppressor 2 homolog {ECO:0000255|HAMAP-Rule:MF_03026};
DE   AltName: Full=Protein lapser1 {ECO:0000255|HAMAP-Rule:MF_03026};
GN   Name=lzts2; Synonyms=lapser1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC       and release from the centrosome. Required for central spindle formation
CC       and the completion of cytokinesis. Negative regulator of the Wnt
CC       signaling pathway. Represses beta-catenin-mediated transcriptional
CC       activation by promoting the nuclear exclusion of beta-catenin.
CC       {ECO:0000255|HAMAP-Rule:MF_03026}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03026}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000255|HAMAP-Rule:MF_03026}.
CC   -!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03026}.
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DR   EMBL; BC084933; AAH84933.1; -; mRNA.
DR   AlphaFoldDB; Q5U4W1; -.
DR   SMR; Q5U4W1; -.
DR   OMA; VTENTMG; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-UniRule.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-UniRule.
DR   GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR   GO; GO:0000281; P:mitotic cytokinesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR   GO; GO:0051168; P:nuclear export; IEA:UniProtKB-UniRule.
DR   GO; GO:0051255; P:spindle midzone assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   HAMAP; MF_03026; LZTS2; 1.
DR   InterPro; IPR045329; LZTS.
DR   InterPro; IPR028597; LZTS2.
DR   PANTHER; PTHR19354; PTHR19354; 1.
DR   PANTHER; PTHR19354:SF4; PTHR19354:SF4; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Microtubule; Mitosis; Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..666
FT                   /note="Leucine zipper putative tumor suppressor 2 homolog"
FT                   /id="PRO_0000367897"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          305..647
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03026"
FT   COMPBIAS        8..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   666 AA;  76301 MW;  497C6804BF14A9A3 CRC64;
     MAAVQALPLS IDQNTEASGS QSHTNTRSPV TENTMGSVSS LISGRTYHDK QCRASEFSNK
     CRKPTNMPNC FKQQEGLLKT NYSSQDFLFN GLPTKKPSTT TSGNNGNYVY VNEDFKEEWH
     DARVPISPSS DAEDIREERS INGNIRGPPP KLIPISGKLE KNVEKTLIKP TAFKPVVPKK
     RNPSLQYLVQ RNGGPGLSES QSSLNLLFNG NSAGIPEKHN SLSCRNIAHS GTMSDSGRTS
     LSSLPTSNTN CSHQLDSVSV SMGHINLDNH SNLNGYSDRA SRGRTRPSNS DSGRSSSSKS
     TGSPILNDEI LIRELEEKLK DREMELQQLK ENLDENEAAI CQVYEEKQKR CEQEMEELRQ
     SCALKMKQAA QKAQRLQQVL QLQIFQLQQE KKKLQEDFSQ LLQERELLEK RCASFEREQT
     EFGPRLEETK WEVCQKSGEI SLLKQQLKDS QAELAQKSNE ILLLRSQFRE ARCDLQISEE
     QVQELQDTAH TKTLEMEVCE NELQRKKNEA ELLREKVSKL DQEVASLREA AVASLRHGLC
     FCHEKEDPFL LYESDEAKAQ RQNADNLQGL QQYVERLREA LASERSRYQE QAEHFEDERR
     KWQEEKEKVI RYQKQLQHNY IQMYQQNREL ERDIKQLTVE LDAREFNEFD LHGAEIHFEE
     ITATEI