LZTS3_HUMAN
ID LZTS3_HUMAN Reviewed; 673 AA.
AC O60299; A2A2Q7; D3DVX6; Q8IXX8;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Leucine zipper putative tumor suppressor 3 {ECO:0000305};
DE AltName: Full=ProSAP-interacting protein 1 {ECO:0000250|UniProtKB:Q8K1Q4};
DE Short=ProSAPiP1 {ECO:0000250|UniProtKB:Q8K1Q4};
GN Name=LZTS3 {ECO:0000312|HGNC:HGNC:30139};
GN Synonyms=KIAA0552 {ECO:0000312|EMBL:BAA25478.2},
GN PROSAPIP1 {ECO:0000250|UniProtKB:Q8K1Q4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in promoting the maturation of dendritic
CC spines, probably via regulating SIPA1L1 levels at the postsynaptic
CC density of synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.
CC -!- SUBUNIT: Interacts (via C-terminus) with SHANK3 (via PDZ domain).
CC Interacts (via coiled coil) with SIPA1L1. Can form homooligomers.
CC {ECO:0000250|UniProtKB:Q8K1Q4}.
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q8K1Q4}.
CC Postsynaptic density {ECO:0000250|UniProtKB:Q8K1Q4}. Cell projection,
CC dendritic spine {ECO:0000250|UniProtKB:Q8K1Q4}. Cell projection,
CC dendrite {ECO:0000250|UniProtKB:Q8K1Q4}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q8K1Q4}. Note=Rather found at excitatory than
CC inhibitory synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O60299-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O60299-2; Sequence=VSP_039202;
CC -!- SIMILARITY: Belongs to the LZTS3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA25478.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB011124; BAA25478.2; ALT_INIT; mRNA.
DR EMBL; AL121891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10545.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10546.1; -; Genomic_DNA.
DR EMBL; CH471133; EAX10547.1; -; Genomic_DNA.
DR EMBL; BC038860; AAH38860.1; -; mRNA.
DR CCDS; CCDS63218.1; -. [O60299-2]
DR PIR; T00328; T00328.
DR RefSeq; NP_001269462.1; NM_001282533.1. [O60299-2]
DR RefSeq; XP_005260949.1; XM_005260892.1.
DR RefSeq; XP_005260950.1; XM_005260893.2. [O60299-1]
DR AlphaFoldDB; O60299; -.
DR SMR; O60299; -.
DR BioGRID; 115109; 26.
DR IntAct; O60299; 8.
DR MINT; O60299; -.
DR STRING; 9606.ENSP00000353496; -.
DR iPTMnet; O60299; -.
DR PhosphoSitePlus; O60299; -.
DR BioMuta; LZTS3; -.
DR EPD; O60299; -.
DR jPOST; O60299; -.
DR MassIVE; O60299; -.
DR MaxQB; O60299; -.
DR PaxDb; O60299; -.
DR PeptideAtlas; O60299; -.
DR PRIDE; O60299; -.
DR ProteomicsDB; 49329; -. [O60299-1]
DR ProteomicsDB; 49330; -. [O60299-2]
DR Antibodypedia; 23459; 93 antibodies from 25 providers.
DR DNASU; 9762; -.
DR Ensembl; ENST00000329152.7; ENSP00000332123.3; ENSG00000088899.16. [O60299-1]
DR Ensembl; ENST00000337576.7; ENSP00000338166.6; ENSG00000088899.16. [O60299-1]
DR Ensembl; ENST00000360342.7; ENSP00000353496.3; ENSG00000088899.16. [O60299-2]
DR Ensembl; ENST00000645462.1; ENSP00000495241.1; ENSG00000088899.16. [O60299-2]
DR GeneID; 9762; -.
DR KEGG; hsa:9762; -.
DR MANE-Select; ENST00000337576.7; ENSP00000338166.6; NM_001365618.1; NP_001352547.1.
DR UCSC; uc002wia.3; human. [O60299-1]
DR CTD; 9762; -.
DR DisGeNET; 9762; -.
DR GeneCards; LZTS3; -.
DR HGNC; HGNC:30139; LZTS3.
DR HPA; ENSG00000088899; Tissue enhanced (brain, retina).
DR MIM; 610484; gene.
DR neXtProt; NX_O60299; -.
DR OpenTargets; ENSG00000088899; -.
DR VEuPathDB; HostDB:ENSG00000088899; -.
DR eggNOG; ENOG502QWFS; Eukaryota.
DR GeneTree; ENSGT00940000154078; -.
DR HOGENOM; CLU_026379_1_0_1; -.
DR InParanoid; O60299; -.
DR OMA; PATCLKP; -.
DR OrthoDB; 363339at2759; -.
DR PhylomeDB; O60299; -.
DR PathwayCommons; O60299; -.
DR SignaLink; O60299; -.
DR BioGRID-ORCS; 9762; 8 hits in 909 CRISPR screens.
DR ChiTaRS; LZTS3; human.
DR GenomeRNAi; 9762; -.
DR Pharos; O60299; Tbio.
DR PRO; PR:O60299; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; O60299; protein.
DR Bgee; ENSG00000088899; Expressed in Brodmann (1909) area 10 and 180 other tissues.
DR Genevisible; O60299; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; ISS:UniProtKB.
DR GO; GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB.
DR InterPro; IPR045329; LZTS.
DR InterPro; IPR033295; LZTS3.
DR PANTHER; PTHR19354; PTHR19354; 1.
DR PANTHER; PTHR19354:SF6; PTHR19354:SF6; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Coiled coil; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome; Synapse.
FT CHAIN 1..673
FT /note="Leucine zipper putative tumor suppressor 3"
FT /id="PRO_0000050760"
FT REGION 1..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 317..496
FT /evidence="ECO:0000255"
FT COILED 571..639
FT /evidence="ECO:0000255"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 316
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2AHG0"
FT MOD_RES 318
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2AHG0"
FT VAR_SEQ 351..396
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039202"
FT CONFLICT 557
FT /note="S -> Y (in Ref. 4; AAH38860)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 673 AA; 71791 MW; 3E548EC03A01F770 CRC64;
MAKLETLPVR ADPGRDPLLA FAPRPSELGP PDPRLAMGSV GSGVAHAQEF AMKSVGTRTG
GGGSQGSFPG PRGSGSGASR ERPGRYPSED KGLANSLYLN GELRGSDHTD VCGNVVGSSG
GSSSSGGSDK APPQYREPSH PPKLLATSGK LDQCSEPLVR PSAFKPVVPK NFHSMQNLCP
PQTNGTPEGR QGPGGLKGGL DKSRTMTPAG GSGSGLSDSG RNSLTSLPTY SSSYSQHLAP
LSASTSHINR IGTASYGSGS GGSSGGGSGY QDLGTSDSGR ASSKSGSSSS MGRPGHLGSG
EGGGGGLPFA ACSPPSPSAL IQELEERLWE KEQEVAALRR SLEQSEAAVA QVLEERQKAW
ERELAELRQG CSGKLQQVAR RAQRAQQGLQ LQVLRLQQDK KQLQEEAARL MRQREELEDK
VAACQKEQAD FLPRIEETKW EVCQKAGEIS LLKQQLKDSQ ADVSQKLSEI VGLRSQLREG
RASLREKEEQ LLSLRDSFSS KQASLELGEG ELPAACLKPA LTPVDPAEPQ DALATCESDE
AKMRRQAGVA AAASLVSVDG EAEAGGESGT RALRREVGRL QAELAAERRA RERQGASFAE
ERRVWLEEKE KVIEYQKQLQ LSYVEMYQRN QQLERRLRER GAAGGASTPT PQHGEEKKAW
TPSRLERIES TEI
