ID   5MP2_XENTR              Reviewed;         419 AA.
AC   Q6P2Z0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=eIF5-mimic protein 2 {ECO:0000250|UniProtKB:Q7L1Q6};
DE   AltName: Full=Basic leucine zipper and W2 domain-containing protein 1;
GN   Name=bzw1; Synonyms=5mp2 {ECO:0000250|UniProtKB:Q7L1Q6};
GN   ORFNames=TEgg065k05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Translation initiation regulator which may repress repeat-
CC       associated non-AUG (RAN) initiated translation probably by acting as a
CC       competitive inhibitor of eukaryotic translation initiation factor 5
CC       (EIF5) function (By similarity). Enhances histone H4 gene transcription
CC       but does not seem to bind DNA directly (By similarity).
CC       {ECO:0000250|UniProtKB:Q7L1Q6}.
CC   -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR   EMBL; CR761210; CAJ81701.1; -; mRNA.
DR   EMBL; BC064244; AAH64244.1; -; mRNA.
DR   EMBL; BC084993; AAH84993.1; -; mRNA.
DR   RefSeq; NP_989281.1; NM_203950.1.
DR   AlphaFoldDB; Q6P2Z0; -.
DR   STRING; 8364.ENSXETP00000058720; -.
DR   PaxDb; Q6P2Z0; -.
DR   DNASU; 394895; -.
DR   GeneID; 394895; -.
DR   KEGG; xtr:394895; -.
DR   CTD; 9689; -.
DR   Xenbase; XB-GENE-5740554; bzw1.
DR   eggNOG; KOG2297; Eukaryota.
DR   InParanoid; Q6P2Z0; -.
DR   OrthoDB; 653740at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000030733; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q6P2Z0; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   CDD; cd11560; W2_eIF5C_like; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043510; W2_BZW1/2.
DR   InterPro; IPR003307; W2_domain.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..419
FT                   /note="eIF5-mimic protein 2"
FT                   /id="PRO_0000254617"
FT   DOMAIN          247..414
FT                   /note="W2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  48164 MW;  60281D96AECF50B9 CRC64;
     MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL NETGNDLEAV AKFLDASGAK
     LDYRRYAETL FDILVAGGML APGGTLADEV IRTDVCVFSA QEDLETMQAF AQVFNKLIRR
     YKYLEKGFEE EVKKLLLFLK GFSESERNKL AMLTGILLAN GNLSASILNS LYNENLVKEG
     VSAAFAVKLF KSWINEKDIN AVAGSLRKVN MDNRLMELFP ANKQTVEHFT KYFTDAGLKE
     LAEYVRNQQT IGARKELQKE LQEMMSRGEP LKEISMYVKD EMKKNNISEQ TVIGILWSSV
     MSCVEWNKKE ELVTEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY DNIHFMKSFQ
     KIVVLFYKAE VLSEEPILKW YKDAHLAKGK SVFLEQMKKF VEWLKNAEEE SESETEEGD