ID   M11L_MYXVL              Reviewed;         166 AA.
AC   Q77PA8;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   29-SEP-2021, entry version 36.
DE   RecName: Full=Apoptosis regulator M11L;
GN   Name=m011L;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16356857; DOI=10.1016/j.immuni.2005.10.003;
RA   Johnston J.B., Barrett J.W., Nazarian S.H., Goodwin M., Ricuttio D.,
RA   Wang G., McFadden G.;
RT   "A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit
RT   host inflammatory and apoptotic responses to infection.";
RL   Immunity 23:587-598(2005).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST BAK1.
RX   PubMed=15194786; DOI=10.1128/jvi.78.13.7097-7111.2004;
RA   Wang G., Barrett J.W., Nazarian S.H., Everett H., Gao X., Bleackley C.,
RA   Colwill K., Moran M.F., McFadden G.;
RT   "Myxoma virus M11L prevents apoptosis through constitutive interaction with
RT   Bak.";
RL   J. Virol. 78:7097-7111(2004).
RN   [4]
RP   FUNCTION, INTERACTION WITH HOST BAX, AND SUBCELLULAR LOCATION.
RX   PubMed=16414991; DOI=10.1128/jvi.80.3.1140-1151.2006;
RA   Su J., Wang G., Barrett J.W., Irvine T.S., Gao X., McFadden G.;
RT   "Myxoma virus M11L blocks apoptosis through inhibition of conformational
RT   activation of Bax at the mitochondria.";
RL   J. Virol. 80:1140-1151(2006).
CC   -!- FUNCTION: Plays a role in the inhibition of mitochondria-mediated
CC       apoptosis by blocking the activation of mitochondria-tranlocalized BAX
CC       thereby maintaining pro-apoptotic BAX in an inactive connformation.
CC       Inhibits also apoptosis in a BAX-independent manner by interacting with
CC       and inhibiting host BAK1 (PubMed:15194786).
CC       {ECO:0000269|PubMed:15194786, ECO:0000269|PubMed:16414991}.
CC   -!- SUBUNIT: Interacts with host BAX; this interaction inhibits apoptosis
CC       activation (PubMed:16414991). Interacts with host BAK1
CC       (PubMed:15194786). {ECO:0000269|PubMed:15194786,
CC       ECO:0000269|PubMed:16414991}.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion {ECO:0000269|PubMed:16414991}.
CC       Host membrane {ECO:0000255}; Single-pass membrane protein
CC       {ECO:0000255}.
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DR   EMBL; AF170726; AAF14899.1; -; Genomic_DNA.
DR   PIR; A44058; A44058.
DR   RefSeq; NP_051725.1; NC_001132.2.
DR   SMR; Q77PA8; -.
DR   GeneID; 932150; -.
DR   KEGG; vg:932150; -.
DR   EvolutionaryTrace; Q77PA8; -.
DR   Proteomes; UP000000867; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.437.10; -; 1.
DR   InterPro; IPR036834; Bcl-2-like_sf.
DR   InterPro; IPR021119; Poxvirus_F1/C10.
DR   Pfam; PF11099; M11L; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Host mitochondrion; Host-virus interaction; Membrane;
KW   Modulation of host cell apoptosis by virus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..166
FT                   /note="Apoptosis regulator M11L"
FT                   /id="PRO_0000443229"
FT   TRANSMEM        138..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   166 AA;  18813 MW;  31A4C719F1E2A3F9 CRC64;
     MMSRLKTAVY DYLNDVDITE CTEMDLLCQL SNCCDFINET YAKNYDTLYD IMERDILSYN
     IVNIKNTLTF ALRDASPSVK LATLTLLASV IKKLNKIQHT DAAMFSEVID GIVAEEQQVI
     GFIQKKCKYN TTYYNVRSGG CKISVYLTAA VVGFVAYGIL KWYRGT