M126_CHICK
ID M126_CHICK Reviewed; 119 AA.
AC P28318;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein MRP-126;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Bone marrow;
RX PubMed=1549365;
RA Nakano T., Graf T.;
RT "Identification of genes differentially expressed in two types of v-myb-
RT transformed avian myelomonocytic cells.";
RL Oncogene 7:527-534(1992).
CC -!- TISSUE SPECIFICITY: Expressed in v-myb-transformed myelomonocytic
CC cells.
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X61200; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001292080.1; NM_001305151.1.
DR AlphaFoldDB; P28318; -.
DR SMR; P28318; -.
DR STRING; 9031.ENSGALP00000022671; -.
DR PaxDb; P28318; -.
DR Ensembl; ENSGALT00000022711; ENSGALP00000022671; ENSGALG00000024272.
DR GeneID; 426356; -.
DR KEGG; gga:426356; -.
DR CTD; 6283; -.
DR VEuPathDB; HostDB:geneid_426356; -.
DR eggNOG; ENOG502SA01; Eukaryota.
DR GeneTree; ENSGT00940000162189; -.
DR HOGENOM; CLU_138624_6_0_1; -.
DR InParanoid; P28318; -.
DR OMA; HEHLHFC; -.
DR OrthoDB; 1521098at2759; -.
DR PhylomeDB; P28318; -.
DR TreeFam; TF332727; -.
DR Reactome; R-GGA-5668599; RHO GTPases Activate NADPH Oxidases.
DR Reactome; R-GGA-5686938; Regulation of TLR by endogenous ligand.
DR Reactome; R-GGA-6798695; Neutrophil degranulation.
DR Reactome; R-GGA-6799990; Metal sequestration by antimicrobial proteins.
DR PRO; PR:P28318; -.
DR Proteomes; UP000000539; Chromosome 25.
DR Bgee; ENSGALG00000024272; Expressed in granulocyte and 8 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..119
FT /note="Protein MRP-126"
FT /id="PRO_0000144025"
FT DOMAIN 23..58
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 59..94
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 37
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="low affinity"
FT /evidence="ECO:0000305"
FT BINDING 42
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="low affinity"
FT /evidence="ECO:0000305"
FT BINDING 72
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 74
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 76
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 78
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 83
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 119 AA; 14065 MW; 2D268DAF6309AD7A CRC64;
MSKGCQTQGP LSELEKAIDV IIDVFHQYSR REGDKDTLTR KELKLLIEKQ LANYLKHVKN
QVSIDQIFKD LDNNKDQQLS FGEVMLLIIR VTVATHEHLH FCEDHQQQHQ HQHQHQHNH