ID   M17L2_DANRE             Reviewed;         199 AA.
AC   Q6DGV7; Q5PR53;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Mpv17-like protein 2;
GN   Name=mpv17l2; ORFNames=zgc:92754;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Liver, and Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly and stability of the mitochondrial
CC       ribosome (By similarity). Is a positive regulator of mitochondrial
CC       protein synthesis (By similarity). {ECO:0000250|UniProtKB:Q567V2}.
CC   -!- SUBUNIT: Interacts with the large mitochondrial ribosomal subunit.
CC       {ECO:0000250|UniProtKB:Q567V2}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q567V2}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; BC076231; AAH76231.1; -; mRNA.
DR   EMBL; BC086824; AAH86824.1; -; mRNA.
DR   RefSeq; NP_001002567.1; NM_001002567.1.
DR   AlphaFoldDB; Q6DGV7; -.
DR   STRING; 7955.ENSDARP00000073314; -.
DR   PaxDb; Q6DGV7; -.
DR   Ensembl; ENSDART00000078854; ENSDARP00000073314; ENSDARG00000056367.
DR   Ensembl; ENSDART00000189577; ENSDARP00000150168; ENSDARG00000112107.
DR   GeneID; 436840; -.
DR   KEGG; dre:436840; -.
DR   CTD; 84769; -.
DR   ZFIN; ZDB-GENE-040718-306; mpv17l2.
DR   eggNOG; KOG1944; Eukaryota.
DR   GeneTree; ENSGT00940000160620; -.
DR   HOGENOM; CLU_049109_4_1_1; -.
DR   InParanoid; Q6DGV7; -.
DR   OMA; FMPLAYR; -.
DR   OrthoDB; 1324608at2759; -.
DR   PhylomeDB; Q6DGV7; -.
DR   TreeFam; TF324392; -.
DR   PRO; PR:Q6DGV7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000056367; Expressed in early embryo and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0061668; P:mitochondrial ribosome assembly; IBA:GO_Central.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..199
FT                   /note="Mpv17-like protein 2"
FT                   /id="PRO_0000317623"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        110
FT                   /note="T -> A (in Ref. 1; AAH86824)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   199 AA;  23198 MW;  659C6D52A143D7E8 CRC64;
     MISRQGKEFL VRIAGYWKPL FRGRFLIVTN TVSCGGMLAA GDLIQQTREI RRTPGRTRDW
     SRTGCMFAVG CSMGPFMHYW YQWLDKYFIG NGINNVCKKV LVDQLVASPT LGAWYFLGMG
     MMEGHTFIEA QQEFRDKFWE FYKADWCVWP AAQMINFYFL PPKFRVLYVN IVTLGWDTYL
     SYLKHRDTVE VTKEADGTA