M17L2_MOUSE
ID M17L2_MOUSE Reviewed; 200 AA.
AC Q8VIK2; Q3THH2; Q80UR1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Mpv17-like protein 2;
GN Name=Mpv17l2; Synonyms=Fksg24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Wang Y.-G., Gong L.;
RT "Characterization of FKSG24, a novel gene located on human chromosome 19.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Bone marrow, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the assembly and stability of the mitochondrial
CC ribosome (By similarity). Is a positive regulator of mitochondrial
CC protein synthesis (By similarity). {ECO:0000250|UniProtKB:Q567V2}.
CC -!- SUBUNIT: Interacts with the large mitochondrial ribosomal subunit.
CC {ECO:0000250|UniProtKB:Q567V2}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q567V2}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; AY013699; AAG38937.1; -; mRNA.
DR EMBL; AK138901; BAE23813.1; -; mRNA.
DR EMBL; AK151477; BAE30432.1; -; mRNA.
DR EMBL; AK152031; BAE30890.1; -; mRNA.
DR EMBL; AK168278; BAE40224.1; -; mRNA.
DR EMBL; BC051227; AAH51227.1; -; mRNA.
DR CCDS; CCDS22380.1; -.
DR RefSeq; NP_898993.1; NM_183170.2.
DR AlphaFoldDB; Q8VIK2; -.
DR STRING; 10090.ENSMUSP00000037929; -.
DR iPTMnet; Q8VIK2; -.
DR PhosphoSitePlus; Q8VIK2; -.
DR EPD; Q8VIK2; -.
DR MaxQB; Q8VIK2; -.
DR PaxDb; Q8VIK2; -.
DR PeptideAtlas; Q8VIK2; -.
DR PRIDE; Q8VIK2; -.
DR ProteomicsDB; 252696; -.
DR Antibodypedia; 51731; 34 antibodies from 16 providers.
DR DNASU; 234384; -.
DR Ensembl; ENSMUST00000038626; ENSMUSP00000037929; ENSMUSG00000035559.
DR GeneID; 234384; -.
DR KEGG; mmu:234384; -.
DR UCSC; uc009mbl.1; mouse.
DR CTD; 84769; -.
DR MGI; MGI:2681846; Mpv17l2.
DR VEuPathDB; HostDB:ENSMUSG00000035559; -.
DR eggNOG; KOG1944; Eukaryota.
DR GeneTree; ENSGT00940000160620; -.
DR HOGENOM; CLU_049109_4_1_1; -.
DR InParanoid; Q8VIK2; -.
DR OMA; FMPLAYR; -.
DR OrthoDB; 1324608at2759; -.
DR PhylomeDB; Q8VIK2; -.
DR TreeFam; TF324392; -.
DR BioGRID-ORCS; 234384; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Mpv17l2; mouse.
DR PRO; PR:Q8VIK2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8VIK2; protein.
DR Bgee; ENSMUSG00000035559; Expressed in adrenal gland and 61 other tissues.
DR ExpressionAtlas; Q8VIK2; baseline and differential.
DR Genevisible; Q8VIK2; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0061668; P:mitochondrial ribosome assembly; ISO:MGI.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; ISS:UniProtKB.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266; PTHR11266; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..200
FT /note="Mpv17-like protein 2"
FT /id="PRO_0000317622"
FT TRANSMEM 24..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 106
FT /note="Q -> R (in Ref. 2; BAE40224)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="Q -> H (in Ref. 3; AAH51227)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 22514 MW; EA801594649610FC CRC64;
MALGGWRWAR KALAAGRPLF QGRALLLTNT LGCGVLMAAG DGARQVWEVR ARPGQRFSAR
RSASMFAVGC SMGPFLHFWY LWLDRLLPAS GLRSLPSVMK KVLVDQTVAS PILGVWYFLG
LGSLEGQTLE ESCQELRAKF WDFYKADWCV WPAAQLVNFL FIPSHFRVTY INGLTLGWDT
YLSYLKYWVP EPLQTPGCAD
