ID   M1_ISAV8                Reviewed;         234 AA.
AC   Q8V3U4;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   29-SEP-2021, entry version 37.
DE   RecName: Full=Matrix protein 1 {ECO:0000303|PubMed:14990725};
DE            Short=M1;
DE   AltName: Full=Protein P6;
DE            Short=P6;
DE   AltName: Full=vp22;
GN   Name=Segment-8 {ECO:0000303|PubMed:20979983}; ORFNames=s8ORF1;
OS   Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99)
OS   (ISAV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Isavirus.
OX   NCBI_TaxID=652965;
OH   NCBI_TaxID=8049; Gadus morhua (Atlantic cod).
OH   NCBI_TaxID=8019; Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OH   NCBI_TaxID=8022; Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OH   NCBI_TaxID=8060; Pollachius virens (Saithe) (Gadus virens).
OH   NCBI_TaxID=8030; Salmo salar (Atlantic salmon).
OH   NCBI_TaxID=8032; Salmo trutta (Brown trout).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11807235; DOI=10.1099/0022-1317-83-2-421;
RA   Clouthier S.C., Rector T., Brown N.E., Anderson E.D.;
RT   "Genomic organization of infectious salmon anaemia virus.";
RL   J. Gen. Virol. 83:421-428(2002).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=14990725; DOI=10.1128/jvi.78.6.3063-3071.2004;
RA   Falk K., Aspehaug V., Vlasak R., Endresen C.;
RT   "Identification and characterization of viral structural proteins of
RT   infectious salmon anemia virus.";
RL   J. Virol. 78:3063-3071(2004).
RN   [3]
RP   REVIEW.
RX   PubMed=20979983; DOI=10.1016/j.virusres.2010.10.021;
RA   Cottet L., Rivas-Aravena A., Cortez-San Martin M., Sandino A.M.,
RA   Spencer E.;
RT   "Infectious salmon anemia virus--genetics and pathogenesis.";
RL   Virus Res. 155:10-19(2011).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HOST HSC70.
RX   PubMed=28202040; DOI=10.1186/s12985-017-0702-z;
RA   Zhang W., Cai C., Lin L., Tao Y.J., Jin M.;
RT   "Subcellular localization and interactions of Infectious Salmon Anemia
RT   Virus (ISAV) M1 and NEP as well as host Hsc70.";
RL   Virol. J. 14:30-30(2017).
CC   -!- FUNCTION: May play a role in virus replication, from virus entry and
CC       uncoating to assembly and budding of the virus particle
CC       (PubMed:20979983). Interaction of viral NEP with M1-Hsc70 is thought to
CC       promote nuclear export of the viral encapsidated genomes
CC       (PubMed:28202040). {ECO:0000303|PubMed:20979983,
CC       ECO:0000303|PubMed:28202040}.
CC   -!- SUBUNIT: Interacts with host HSC70. {ECO:0000269|PubMed:28202040}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:14990725}. Host
CC       cytoplasm {ECO:0000269|PubMed:28202040}. Host nucleus
CC       {ECO:0000269|PubMed:28202040}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Matrix protein 1;
CC         IsoId=Q8V3U4-1; Sequence=Displayed;
CC       Name=Matrix protein 2;
CC         IsoId=Q8V3U3-1; Sequence=External;
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DR   EMBL; AF404340; AAL67954.1; -; Genomic_RNA.
DR   RefSeq; YP_145796.1; NC_006497.1.
DR   SMR; Q8V3U4; -.
DR   GeneID; 5075847; -.
DR   KEGG; vg:5075847; -.
DR   Proteomes; UP000008772; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Host cytoplasm; Host nucleus;
KW   Reference proteome; Virion.
FT   CHAIN           1..234
FT                   /note="Matrix protein 1"
FT                   /id="PRO_0000403924"
FT   REGION          1..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          183..234
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   234 AA;  26539 MW;  51072C3F92545CB0 CRC64;
     MHERSKPKTT GADQTCLEEE KETRGGLRNG SSSDTGGRER TDRGVSCSRR KNCEGQNLEP
     IGERDDQSSD DDPLLCDERS TIGRHGNADE RPHQELAEGG IRMPGRGWWR GKMGNGVWYD
     FTRHGRGEDD AEGAENNATQ QDADVCSGCK FESPREFRKG HRRCSSSTSG ILLDREDGAS
     GVPEVSFKER MEAEKKKLKE LDDKIYKLRR RLRKMEYKKM GINREIDKLE DSVQ