ID   M1_THOGV                Reviewed;         266 AA.
AC   Q77D96;
DT   31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   29-SEP-2021, entry version 32.
DE   RecName: Full=Matrix protein;
DE            Short=M1;
GN   OrderedLocusNames=Segment 6;
OS   Thogoto virus (isolate SiAr 126) (Tho).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Thogotovirus.
OX   NCBI_TaxID=126796 {ECO:0000312|Proteomes:UP000008973};
OH   NCBI_TaxID=34610; Amblyomma variegatum (Tropical bont tick).
OH   NCBI_TaxID=10144; Cavia cutleri (Guinea pig).
OH   NCBI_TaxID=210652; Mungos mungo (Banded mongoose).
OH   NCBI_TaxID=34631; Rhipicephalus appendiculatus (Brown ear tick).
OH   NCBI_TaxID=6941; Rhipicephalus microplus (Cattle tick) (Boophilus microplus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC RNA].
RX   PubMed=1733105; DOI=10.1016/0042-6822(92)90030-s;
RA   Morse M.A., Marriott A.C., Nuttall P.A.;
RT   "The glycoprotein of Thogoto virus (a tick-borne orthomyxo-like virus) is
RT   related to the baculovirus glycoprotein GP64.";
RL   Virology 186:640-646(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC RNA].
RX   PubMed=8970956; DOI=10.1128/jvi.70.12.8361-8367.1996;
RA   Weber F., Haller O., Kochs G.;
RT   "Nucleoprotein viral RNA and mRNA of Thogoto virus: a novel 'cap-stealing'
RT   mechanism in tick-borne orthomyxoviruses?";
RL   J. Virol. 70:8361-8367(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC RNA].
RX   PubMed=9282786; DOI=10.1016/s0168-1702(97)00072-5;
RA   Leahy M.B., Dessens J.T., Weber F., Kochs G., Nuttall P.A.;
RT   "The fourth genus in the Orthomyxoviridae: sequence analyses of two Thogoto
RT   virus polymerase proteins and comparison with influenza viruses.";
RL   Virus Res. 50:215-224(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC RNA].
RX   PubMed=10486113; DOI=10.1007/s007050050613;
RA   Weber F., Gruber S., Haller O., Kochs G.;
RT   "PB2 polymerase subunit of Thogoto virus (Orthomyxoviridae family).";
RL   Arch. Virol. 144:1601-1609(1999).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC RNA].
RX   PubMed=12552016; DOI=10.1128/jvi.77.4.2747-2752.2003;
RA   Hagmaier K., Jennings S., Buse J., Weber F., Kochs G.;
RT   "Novel gene product of Thogoto virus segment 6 codes for an interferon
RT   antagonist.";
RL   J. Virol. 77:2747-2752(2003).
RN   [6]
RP   FUNCTION.
RX   PubMed=11044123; DOI=10.1128/jvi.74.22.10785-10789.2000;
RA   Kochs G., Weber F., Gruber S., Delvendahl A., Leitz C., Haller O.;
RT   "Thogoto virus matrix protein is encoded by a spliced mRNA.";
RL   J. Virol. 74:10785-10789(2000).
CC   -!- FUNCTION: plays a role in virion budding and release by presumably
CC       binding the ribonucleocapsid and the host membrane.
CC       {ECO:0000305|PubMed:11044123}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Matrix protein;
CC         IsoId=Q77D96-1; Sequence=Displayed;
CC       Name=Protein ML;
CC         IsoId=Q80A33-1; Sequence=External;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF527531; AAO49498.1; -; Genomic_RNA.
DR   RefSeq; YP_145806.1; NC_006504.1.
DR   SMR; Q77D96; -.
DR   GeneID; 5075735; -.
DR   KEGG; vg:5075735; -.
DR   Proteomes; UP000008973; Genome.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   InterPro; IPR035212; Mx/ML_C.
DR   Pfam; PF17536; Mx_ML; 1.
PE   4: Predicted;
KW   Alternative splicing; Reference proteome; Viral matrix protein; Virion.
FT   CHAIN           1..266
FT                   /note="Matrix protein"
FT                   /id="PRO_0000443066"
SQ   SEQUENCE   266 AA;  29852 MW;  D6C25FDDA2B49546 CRC64;
     MASNLPVRSF SEVCCAEARA AIIQMENNPD ETVCNRIWKI HRDLQSSDLT TTVQVMMVYR
     FISKRVPEGC FAILSGVNTG MYNPRELKRS YVQSLSSGTS CEFLRSLDKL AKNLLAVHVC
     SDVKMSLNKR QVIDFISGEE DPTLHTAEHL TSLALDDSPS AVVYSGWQQE AIKLHNTIRK
     IATMRPADCK AGKFYSDILS ACDQTKELLD AFDQGKLAYD RDVVLIGWMD EIIKIFSKPD
     YLEAKGVSYQ VLKNVSNKVA LLRESI