ID   M1_VACCC                Reviewed;         472 AA.
AC   P20640;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 84.
DE   RecName: Full=Ankyrin repeat protein M1;
GN   ORFNames=M1L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: This protein may be responsible for resistance to alpha-
CC       amanitin.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae M1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48003.1; -; Genomic_DNA.
DR   PIR; G42504; G42504.
DR   SMR; P20640; -.
DR   Proteomes; UP000008269; Genome.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF00023; Ank; 2.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Early protein; Reference proteome; Repeat.
FT   CHAIN           1..472
FT                   /note="Ankyrin repeat protein M1"
FT                   /id="PRO_0000067098"
FT   REPEAT          97..126
FT                   /note="ANK 1"
FT   REPEAT          130..161
FT                   /note="ANK 2"
FT   REPEAT          233..263
FT                   /note="ANK 3"
FT   REPEAT          267..297
FT                   /note="ANK 4"
FT   REPEAT          322..351
FT                   /note="ANK 5"
FT   REPEAT          353..377
FT                   /note="ANK 6"
SQ   SEQUENCE   472 AA;  54183 MW;  BBE3BFBBD4846DFF CRC64;
     MIFVIESKLL QIYRNRNRNI NFYTTMDNIM SAEYYLSLYA KYNSKNLDVF RNMLQAIEPS
     GNNYHILHAY CGIKGLDERF VEELLHRGYS PNETDDDGNY PLHIASKINN NRIVAMLLTH
     GADPNACDKH NKTPLYYLSG TDDEVIERIN LLVQYGAKIN NSVDEEGCGP LLACTDPSER
     VFKKIMSIGF EARIVDKFGK NHIHRHLMSD NPKASTISWM MKLGISPSKP DHDGNTPLHI
     VCSKTVKNVD IIDLLLPSTD VNKQNKFGDS PLTLLIKTLS PAHLINKLLS TSNVITDQTV
     NICIFYDRDD VLEIINDKGK QYDSTDFKMA VEVGSIRCVK YLLDNDIICE DAMYYAVLSE
     YETMVDYLLF NHFSVDSVVN GHTCMSECVR LNNPVILSKL MLHNPTSETM YLTMKAIEKD
     KLDKSIIIPF IAYFVLMHPD FCKNRRYFTS YKRFVTDYVH EGVSYEVFDD YF