ID   M1_VACCW                Reviewed;         472 AA.
AC   P14356; Q80HY3; Q85333;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 2.
DT   23-FEB-2022, entry version 87.
DE   RecName: Full=Ankyrin repeat protein M1;
GN   OrderedLocusNames=VACWR030; ORFNames=M1L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3388767; DOI=10.1016/0042-6822(88)90667-8;
RA   Tamin A., Villarreal E.C., Weinrich S.L., Hruby D.E.;
RT   "Nucleotide sequence and molecular genetic analysis of the vaccinia virus
RT   HindIII N/M region encoding the genes responsible for resistance to alpha-
RT   amanitin.";
RL   Virology 165:141-150(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-421.
RX   PubMed=2849238; DOI=10.1016/s0042-6822(88)90115-8;
RA   Kotwal G.J., Moss B.;
RT   "Analysis of a large cluster of nonessential genes deleted from a vaccinia
RT   virus terminal transposition mutant.";
RL   Virology 167:524-537(1988).
CC   -!- FUNCTION: This protein may be responsible for resistance to alpha-
CC       amanitin.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae M1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M20779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY243312; AAO89309.1; -; Genomic_DNA.
DR   EMBL; M23701; AAA69591.1; -; Genomic_DNA.
DR   PIR; A29196; FOVZM1.
DR   RefSeq; YP_232912.1; NC_006998.1.
DR   SMR; P14356; -.
DR   DNASU; 3707645; -.
DR   GeneID; 3707645; -.
DR   KEGG; vg:3707645; -.
DR   Proteomes; UP000000344; Genome.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF00023; Ank; 2.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Early protein; Reference proteome; Repeat.
FT   CHAIN           1..472
FT                   /note="Ankyrin repeat protein M1"
FT                   /id="PRO_0000067099"
FT   REPEAT          97..126
FT                   /note="ANK 1"
FT   REPEAT          130..161
FT                   /note="ANK 2"
FT   REPEAT          233..263
FT                   /note="ANK 3"
FT   REPEAT          267..297
FT                   /note="ANK 4"
FT   REPEAT          322..351
FT                   /note="ANK 5"
FT   REPEAT          353..377
FT                   /note="ANK 6"
FT   CONFLICT        81
FT                   /note="V -> VE (in Ref. 1; AAO89309)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   472 AA;  54271 MW;  D08E09732499D51B CRC64;
     MIFVIESKLL QIYRNRNRNI NFYTTMDNIM SAEYYLSLYA KYNSKNLDVF RNMLQAIEPS
     GNNYHILHAY CGIKGLDERF VEELLHRGYS PNETDDDGNY PLHIASKINN NRIVAMLLTH
     GADPNACDKH NKTPLYYLSG TDDEVIERIN LLVQYGAKIN NSVDEEGCGP LLACTDPSER
     VFKKIMSIGF EARIVDKFGK NHIHRHLMSD NPKASTISWM MKLGISPSKP DHDGNTPLHI
     VCSKTVKNVD IIDLLLPSTD VNKQNKFGDS PLTLLIKTLS PAHLINKLLS TSNVITDQTV
     NICIFYDRDD VLEIINDKGK QYDSTDFKMA VEVGSIRCVK YLLDNDIICE DAMYYAVLSE
     YETMVDYLLF NHFSVDFVVN GHTCMSECVR LNNPVILSKL MLHNPTSETM YLTMKAIEKD
     RLDKSIIIPF IAYFVLMHPD FCKNRRYFTS YKRFVTDYVH EGVSYEVFDD YF