ID   M1_VAR67                Reviewed;         446 AA.
AC   P33825;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Ankyrin repeat protein M1;
GN   ORFNames=M1L, O1L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: This protein may be responsible for resistance to alpha-
CC       amanitin.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae M1 protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA48959.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X69198; CAA48959.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_042062.1; NC_001611.1.
DR   SMR; P33825; -.
DR   GeneID; 1486478; -.
DR   KEGG; vg:1486478; -.
DR   Proteomes; UP000002060; Genome.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   Pfam; PF00023; Ank; 2.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; SSF48403; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..446
FT                   /note="Ankyrin repeat protein M1"
FT                   /id="PRO_0000067100"
FT   REPEAT          71..100
FT                   /note="ANK 1"
FT   REPEAT          104..135
FT                   /note="ANK 2"
FT   REPEAT          207..237
FT                   /note="ANK 3"
FT   REPEAT          241..271
FT                   /note="ANK 4"
FT   REPEAT          296..325
FT                   /note="ANK 5"
FT   REPEAT          327..351
FT                   /note="ANK 6"
SQ   SEQUENCE   446 AA;  50970 MW;  FE8F1CFD46F7E237 CRC64;
     MDNIMSAEYY LSLYTKYNSK NLDVFRNMLQ AIEPSGNYHI LHAYCGIKGL DERFVEELLH
     RGYSPNETDD DGNYPLHIAS KINNNRIVAM LLTHGADPNA CDKQHKTPLY YLSGTDDEVI
     ERINLLVQYG AKINNSVDEE GCGPLLASTD PSERVFKKIM SIGFEARIVD KFGKNHIHRH
     LMSDNPKAST ISWMMKLGIS PSKPDHDGNT PLHIVCSKTV KNVDIINLLL PSTDVNKQNK
     FGDSPLTLLI KTLSPAHLIN KLLSTSNVIT DQTVNICIFY DRDDILEIIN DKGKQYDSTD
     FKMAVEVGSI RCIKYLLDND IICEDAMYYA VLSEYETMVD YLLFNHFSVD SVVNGNTCMS
     ECVRLNNPVI LSKLMLHNPT SETMYLTMKA IEKDKLDKSI IIPFIAYFVL MHPDFCKNRR
     YFTSYKRFVT DYVHEGVSYK VFDDYF