ID   M212A_XENLA             Reviewed;         359 AA.
AC   Q9I9K2; O73740;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein mab-21-like 2-A;
DE   AltName: Full=XMab21l2;
DE            Short=Xmab-21;
GN   Name=mab21l2-a; Synonyms=mab21l2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11162683; DOI=10.1006/bbrc.2001.4290;
RA   Lau G.T.C., Wong O.G.W., Chan P.M.Y., Kok K.-H., Wong R.L.Y., Chin K.-T.,
RA   Lin M.C.M., Kung H.-F., Chow K.L.;
RT   "Embryonic XMab21l2 expression is required for gastrulation and subsequent
RT   neural development.";
RL   Biochem. Biophys. Res. Commun. 280:1378-1384(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Head;
RX   PubMed=15613244; DOI=10.1186/1471-2121-5-48;
RA   Baldessari D., Badaloni A., Longhi R., Zappavigna V., Consalez G.G.;
RT   "MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP
RT   signaling and interacts with SMAD1.";
RL   BMC Cell Biol. 5:48-48(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal development of the eye (By similarity).
CC       May promote dorsalization of the developing embryo by antagonizing the
CC       ventralizing factor bmp4. Functional antagonism of bmp4 may require
CC       interaction with smad1. Required for gastrulation and subsequent neural
CC       development. May function as a transcriptional repressor.
CC       {ECO:0000250|UniProtKB:Q8BPP1, ECO:0000269|PubMed:11162683,
CC       ECO:0000269|PubMed:15613244}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y586}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9Y586}. Note=Predominantly localizes to the
CC       nucleus, with some cytoplasmic localization.
CC       {ECO:0000250|UniProtKB:Q9Y586}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, during
CC       and after gastrulation. Expressed in neurulating embryos at the neural
CC       tube, the optic tissue, the developing midbrain and the pharyngeal
CC       pouches. Expressed at the tailbud stage in the primitive eye field, the
CC       optic recess, the optic cup, the retina, the tectum, the dorsal neural
CC       tube and the branchial arches. {ECO:0000269|PubMed:11162683,
CC       ECO:0000269|PubMed:15613244}.
CC   -!- SIMILARITY: Belongs to the mab-21 family. {ECO:0000305}.
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DR   EMBL; AF240183; AAF67175.1; -; Genomic_DNA.
DR   EMBL; AF040992; AAC15657.1; -; mRNA.
DR   EMBL; BC074421; AAH74421.1; -; mRNA.
DR   RefSeq; NP_001083740.1; NM_001090271.1.
DR   AlphaFoldDB; Q9I9K2; -.
DR   SMR; Q9I9K2; -.
DR   DNASU; 399091; -.
DR   GeneID; 399091; -.
DR   CTD; 399091; -.
DR   Xenbase; XB-GENE-983452; mab21l2.L.
DR   OMA; RCLSMLK; -.
DR   OrthoDB; 771781at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 399091; Expressed in camera-type eye and 9 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0001654; P:eye development; ISS:UniProtKB.
DR   InterPro; IPR024810; Mab-21_dom.
DR   InterPro; IPR020950; Mab21-l2.
DR   PANTHER; PTHR10656:SF37; PTHR10656:SF37; 1.
DR   Pfam; PF03281; Mab-21; 1.
DR   SMART; SM01265; Mab-21; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..359
FT                   /note="Protein mab-21-like 2-A"
FT                   /id="PRO_0000312790"
FT   CONFLICT        96
FT                   /note="G -> A (in Ref. 2; AAC15657)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        103
FT                   /note="S -> G (in Ref. 2; AAC15657)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   359 AA;  40830 MW;  035686F92C8B427A CRC64;
     MIAAQAKLVY QLNKYYSERC QARKGAIAKT IREVCKVVSD VLKEVEVQEP RFISSLTEID
     ARYEGLEVVC PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS
     GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MIADTSEVKL RIRERYIVQI TPAFKCTGIW
     PRSAAQWPLP HIPWPGPNRV AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFAEAENR
     LLLGGCRGKC LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDEACLGDRL
     NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL TNPKSLDKL