ID   ARGFX_HUMAN             Reviewed;         315 AA.
AC   A6NJG6;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Arginine-fifty homeobox {ECO:0000305};
GN   Name=ARGFX {ECO:0000312|HGNC:HGNC:30146};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=27412763; DOI=10.1038/srep28995;
RA   Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA   Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA   Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT   "Characterization and target genes of nine human PRD-like homeobox domain
RT   genes expressed exclusively in early embryos.";
RL   Sci. Rep. 6:28995-28995(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=17005330; DOI=10.1016/j.gene.2006.07.034;
RA   Booth H.A., Holland P.W.H.;
RT   "Annotation, nomenclature and evolution of four novel homeobox genes
RT   expressed in the human germ line.";
RL   Gene 387:7-14(2007).
CC   -!- FUNCTION: Transcription factor that acts as activator.
CC       {ECO:0000269|PubMed:27412763}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed at low level in testis and
CC       undifferentiated embryonic stem cells. {ECO:0000269|PubMed:17005330}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC       embryos. {ECO:0000269|PubMed:27412763}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; LN901400; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC069239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS33834.1; -.
DR   RefSeq; NP_001012677.1; NM_001012659.1.
DR   AlphaFoldDB; A6NJG6; -.
DR   SMR; A6NJG6; -.
DR   STRING; 9606.ENSP00000335578; -.
DR   iPTMnet; A6NJG6; -.
DR   PhosphoSitePlus; A6NJG6; -.
DR   BioMuta; ARGFX; -.
DR   EPD; A6NJG6; -.
DR   MassIVE; A6NJG6; -.
DR   PaxDb; A6NJG6; -.
DR   PRIDE; A6NJG6; -.
DR   TopDownProteomics; A6NJG6; -.
DR   Antibodypedia; 32829; 106 antibodies from 18 providers.
DR   DNASU; 503582; -.
DR   Ensembl; ENST00000334384.5; ENSP00000335578.3; ENSG00000186103.5.
DR   Ensembl; ENST00000651603.1; ENSP00000498601.1; ENSG00000186103.5.
DR   GeneID; 503582; -.
DR   KEGG; hsa:503582; -.
DR   MANE-Select; ENST00000334384.5; ENSP00000335578.3; NM_001012659.2; NP_001012677.1.
DR   UCSC; uc062myc.1; human.
DR   CTD; 503582; -.
DR   GeneCards; ARGFX; -.
DR   HGNC; HGNC:30146; ARGFX.
DR   HPA; ENSG00000186103; Tissue enhanced (brain).
DR   MIM; 611164; gene.
DR   neXtProt; NX_A6NJG6; -.
DR   OpenTargets; ENSG00000186103; -.
DR   PharmGKB; PA142672588; -.
DR   VEuPathDB; HostDB:ENSG00000186103; -.
DR   eggNOG; KOG2251; Eukaryota.
DR   GeneTree; ENSGT00730000111572; -.
DR   HOGENOM; CLU_077853_0_0_1; -.
DR   InParanoid; A6NJG6; -.
DR   OMA; NRMAPGN; -.
DR   OrthoDB; 1020170at2759; -.
DR   PhylomeDB; A6NJG6; -.
DR   TreeFam; TF351179; -.
DR   PathwayCommons; A6NJG6; -.
DR   SignaLink; A6NJG6; -.
DR   BioGRID-ORCS; 503582; 280 hits in 1057 CRISPR screens.
DR   GenomeRNAi; 503582; -.
DR   Pharos; A6NJG6; Tdark.
DR   PRO; PR:A6NJG6; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A6NJG6; protein.
DR   Bgee; ENSG00000186103; Expressed in mucosa of large intestine and 2 other tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..315
FT                   /note="Arginine-fifty homeobox"
FT                   /id="PRO_0000311325"
FT   DNA_BIND        78..137
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          135..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         145
FT                   /note="R -> Q (in dbSNP:rs9813391)"
FT                   /id="VAR_037226"
FT   CONFLICT        30
FT                   /note="D -> G (in Ref. 1; LN901400)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   315 AA;  35617 MW;  D3EDBA45BAB43352 CRC64;
     MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA YCSLNLPGST
     DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT MFPDRNLQEK LALRLDLPES
     TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP SKKNVPTSPR TSPSPYAFSP VISDFYSSLP
     SQPLDPSNWA WNSTFTESST SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN
     EISSSSFHCL YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS
     LEFQKTSNMV DLGFL