ID   M22_AMPV1               Reviewed;          71 AA.
AC   Q2Y2M1;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   10-FEB-2021, entry version 39.
DE   RecName: Full=Protein M2-2;
GN   Name=M2-2;
OS   Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus.
OX   NCBI_TaxID=652954;
OH   NCBI_TaxID=8847; Anser sp. (goose).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15666873; DOI=10.1637/7208-051804r;
RA   Bennett R.S., Nezworski J., Velayudhan B.T., Nagaraja K.V., Zeman D.H.,
RA   Dyer N., Graham T., Lauer D.C., Njenga M.K., Halvorson D.A.;
RT   "Evidence of avian pneumovirus spread beyond Minnesota among wild and
RT   domestic birds in central North America.";
RL   Avian Dis. 48:902-908(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16282483; DOI=10.1128/jvi.79.23.14834-14842.2005;
RA   Bennett R.S., LaRue R., Shaw D., Yu Q., Nagaraja K.V., Halvorson D.A.,
RA   Njenga M.K.;
RT   "A wild goose metapneumovirus containing a large attachment glycoprotein is
RT   avirulent but immunoprotective in domestic turkeys.";
RL   J. Virol. 79:14834-14842(2005).
CC   -!- FUNCTION: Mediates the regulatory switch from transcription to RNA
CC       replication. Acts late in infection by inhibiting viral transcription
CC       and up-regulating RNA replication (By similarity). Plays a major role
CC       in antagonizing the type I IFN-mediated antiviral response. Interacts
CC       with host MAVS and prevents the interaction with its upstream partner
CC       DDX58/RIG-I in the signaling pathway leading to interferon production
CC       (By similarity). {ECO:0000250|UniProtKB:P88812,
CC       ECO:0000250|UniProtKB:Q6WB96}.
CC   -!- SUBUNIT: Interacts with host MAVS; this interaction inhibits signaling
CC       pathway leading to interferon production.
CC       {ECO:0000250|UniProtKB:Q6WB96}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P88812}.
CC   -!- SIMILARITY: Belongs to the metapneumovirus M2-2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; DQ009484; AAY81659.1; -; Viral_cRNA.
DR   RefSeq; YP_443842.1; NC_007652.1.
DR   Proteomes; UP000002471; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Viral RNA replication.
FT   CHAIN           1..71
FT                   /note="Protein M2-2"
FT                   /id="PRO_0000390375"
SQ   SEQUENCE   71 AA;  8251 MW;  C4D5EF475BC4904E CRC64;
     MTLQLPCKIV QTLIKCGEHG LIFLKMKLDD MVWTKNELVD IISTEIVKVH ANIFKCRLED
     IEIIYVNTFL S