ID   M22_BRSVA               Reviewed;          90 AA.
AC   Q77KZ6; Q8V687;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   07-APR-2021, entry version 45.
DE   RecName: Full=Protein M2-2;
GN   Name=M2-2;
OS   Bovine respiratory syncytial virus (strain A51908) (BRS).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.
OX   NCBI_TaxID=11247;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11724268; DOI=10.1023/a:1011888019966;
RA   Yunus A.S., Khattar S.K., Collins P.L., Samal S.K.;
RT   "Rescue of bovine respiratory syncytial virus from cloned cDNA: entire
RT   genome sequence of BRSV strain A51908.";
RL   Virus Genes 23:157-164(2001).
CC   -!- FUNCTION: Mediates the regulatory switch from transcription to RNA
CC       replication. Acts late in infection by inhibiting viral transcription
CC       and up-regulating RNA replication. Inhibition of transcription by
CC       protein M2-2 requires phosphorylation of the phosphoprotein.
CC       {ECO:0000250|UniProtKB:P88812}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P88812}.
CC   -!- SIMILARITY: Belongs to the orthopneumovirus M2-2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF295543; AAL49401.1; -; Genomic_RNA.
DR   EMBL; AF295544; AAL49412.1; -; Genomic_RNA.
DR   Proteomes; UP000007616; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009969; Pneumo_M2-2.
DR   Pfam; PF07380; Pneumo_M2; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Viral RNA replication.
FT   CHAIN           1..90
FT                   /note="Protein M2-2"
FT                   /id="PRO_0000365793"
FT   VARIANT         24
FT                   /note="D -> N (in strain:ATCC51908)"
FT   VARIANT         29
FT                   /note="F -> I (in strain:ATCC51908)"
FT   VARIANT         39
FT                   /note="C -> Y (in strain:ATCC51908)"
FT   VARIANT         46
FT                   /note="Y -> C (in strain:ATCC51908)"
FT   VARIANT         81
FT                   /note="N -> S (in strain:ATCC51908)"
SQ   SEQUENCE   90 AA;  10602 MW;  B4829A3C3083C1D0 CRC64;
     MNNSNIIIFP EKYPCSISSL LIKDENDVFV LSHQNVLDCL QFQYPYNMYS QNHMLDDIYW
     TSQELIEDVL KILHLSGISI NKYVIYVLVL