ID   M22_HMPVC               Reviewed;          71 AA.
AC   Q6WB96;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Protein M2-2;
GN   Name=M2;
OS   Human metapneumovirus (strain CAN97-83) (HMPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus.
OX   NCBI_TaxID=694067;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=14592754; DOI=10.1016/s0042-6822(03)00528-2;
RA   Biacchesi S., Skiadopoulos M.H., Boivin G., Hanson C.T., Murphy B.R.,
RA   Collins P.L., Buchholz U.J.;
RT   "Genetic diversity between human metapneumovirus subgroups.";
RL   Virology 315:1-9(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16306583; DOI=10.1128/jvi.79.24.15114-15122.2005;
RA   Pham Q.N., Biacchesi S., Skiadopoulos M.H., Murphy B.R., Collins P.L.,
RA   Buchholz U.J.;
RT   "Chimeric recombinant human metapneumoviruses with the nucleoprotein or
RT   phosphoprotein open reading frame replaced by that of avian metapneumovirus
RT   exhibit improved growth in vitro and attenuation in vivo.";
RL   J. Virol. 79:15114-15122(2005).
RN   [3]
RP   INTERACTION WITH HOST MAVS, AND FUNCTION.
RX   PubMed=23015697; DOI=10.1128/jvi.01248-12;
RA   Ren J., Wang Q., Kolli D., Prusak D.J., Tseng C.T., Chen Z.J., Li K.,
RA   Wood T.G., Bao X.;
RT   "Human metapneumovirus M2-2 protein inhibits innate cellular signaling by
RT   targeting MAVS.";
RL   J. Virol. 86:13049-13061(2012).
CC   -!- FUNCTION: Mediates the regulatory switch from transcription to RNA
CC       replication (By similarity). Acts late in infection by inhibiting viral
CC       transcription and up-regulating RNA replication (By similarity). Plays
CC       a major role in antagonizing the type I IFN-mediated antiviral response
CC       (PubMed:23015697). Interacts with host MAVS and prevents the
CC       interaction with its upstream partner DDX58/RIG-I in the signaling
CC       pathway leading to interferon production (PubMed:23015697).
CC       {ECO:0000250|UniProtKB:P88812, ECO:0000269|PubMed:23015697}.
CC   -!- SUBUNIT: Interacts with host MAVS; this interaction inhibits signaling
CC       pathway leading to interferon production.
CC       {ECO:0000269|PubMed:23015697}.
CC   -!- INTERACTION:
CC       Q6WB96; Q7Z434: MAVS; Xeno; NbExp=4; IntAct=EBI-6863628, EBI-995373;
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P88812}.
CC   -!- SIMILARITY: Belongs to the metapneumovirus M2-2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AY297749; AAQ67697.1; -; Genomic_RNA.
DR   RefSeq; YP_012610.1; NC_004148.2.
DR   IntAct; Q6WB96; 1.
DR   PRIDE; Q6WB96; -.
DR   Proteomes; UP000001398; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039545; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host MAVS by virus; Inhibition of host RLR pathway by virus;
KW   Reference proteome; Viral immunoevasion; Viral RNA replication.
FT   CHAIN           1..71
FT                   /note="Protein M2-2"
FT                   /id="PRO_0000394813"
SQ   SEQUENCE   71 AA;  8189 MW;  0887B853B81A8125 CRC64;
     MTLHMPCKTV KALIKCSEHG PVFITIEVDE MIWTQKELKE ALSDGIVKSH TNIYNCYLEN
     IEIIYVKAYL S