ID   M22_HRSVB               Reviewed;          90 AA.
AC   O42047;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   02-JUN-2021, entry version 56.
DE   RecName: Full=Protein M2-2;
GN   Name=M2-2;
OS   Human respiratory syncytial virus B (strain B1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Orthopneumovirus.
OX   NCBI_TaxID=79692;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9391135; DOI=10.1073/pnas.94.25.13961;
RA   Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E.,
RA   Clements-Mann M.L., Harris D.O., Randolph V.B., Udem S.A., Murphy B.R.,
RA   Sidhu M.S.;
RT   "Respiratory syncytial virus (RSV) SH and G proteins are not essential for
RT   viral replication in vitro: clinical evaluation and molecular
RT   characterization of a cold-passaged, attenuated RSV subgroup B mutant.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:13961-13966(1997).
CC   -!- FUNCTION: Mediates the regulatory switch from transcription to RNA
CC       replication. Acts late in infection by inhibiting viral transcription
CC       and up-regulating RNA replication. Inhibition of transcription by
CC       protein M2-2 requires phosphorylation of the phosphoprotein.
CC       {ECO:0000250|UniProtKB:P88812}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P88812}.
CC   -!- SIMILARITY: Belongs to the orthopneumovirus M2-2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF013254; AAB82438.1; -; Genomic_RNA.
DR   EMBL; AF013255; AAB82448.1; -; Genomic_RNA.
DR   RefSeq; NP_056865.1; NC_001781.1.
DR   PRIDE; O42047; -.
DR   GeneID; 1489826; -.
DR   Proteomes; UP000002472; Genome.
DR   Proteomes; UP000180717; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009969; Pneumo_M2-2.
DR   Pfam; PF07380; Pneumo_M2; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Viral RNA replication.
FT   CHAIN           1..90
FT                   /note="Protein M2-2"
FT                   /id="PRO_0000365794"
SQ   SEQUENCE   90 AA;  10587 MW;  16D886E983DE3994 CRC64;
     MTKPKIMILP DKYPCSISSI LISSESMIAT FNHKNILQFN HNHLDNHQRL LNNIFDEIHW
     TPKNLLDATQ QFLQHLNIPE DIYTIYILVS