M233_CONTS
ID M233_CONTS Reviewed; 67 AA.
AC Q9BPI6;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Conotoxin TsMMSK-011;
DE AltName: Full=Conotoxin TsMMSK-B012;
DE Flags: Precursor;
OS Conus tessulatus (Tessellate cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX NCBI_TaxID=101317;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL Mol. Biol. Evol. 18:120-131(2001).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 2 branch, since 2 residues stand between the fourth and the fifth
CC cysteine residues.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR EMBL; AF214938; AAG60366.1; -; mRNA.
DR AlphaFoldDB; Q9BPI6; -.
DR ConoServer; 625; Ts3.3 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Hydroxylation;
KW Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..50
FT /evidence="ECO:0000250"
FT /id="PRO_0000404898"
FT PEPTIDE 53..67
FT /note="Conotoxin TsMMSK-011"
FT /id="PRO_0000404899"
FT MOD_RES 63
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000250"
FT DISULFID 53..65
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT DISULFID 54..61
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT DISULFID 58..64
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ SEQUENCE 67 AA; 7502 MW; 20E8D096AEEFD16D CRC64;
MMSKLGVLLT ICLLLFPLTA VQLDGDQPAD LPALRTQDIS TDHSPWFDPV KRCCSRYCYI
CIPCCPN