ID   M237_CONTS              Reviewed;          68 AA.
AC   Q9BPJ9;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Conotoxin TsMMSK-021;
DE   AltName: Full=Conotoxin TsMMSK-022;
DE   Flags: Precursor;
OS   Conus tessulatus (Tessellate cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX   NCBI_TaxID=101317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:11158371}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:11158371}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   EMBL; AF214924; AAG60352.1; -; mRNA.
DR   AlphaFoldDB; Q9BPJ9; -.
DR   ConoServer; 611; TsMMSK-021 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Hydroxylation;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..50
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000404910"
FT   PEPTIDE         53..68
FT                   /note="Conotoxin TsMMSK-021"
FT                   /id="PRO_0000404911"
FT   MOD_RES         64
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..66
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        54..62
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        58..65
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   68 AA;  7526 MW;  C6C4B30552DDC946 CRC64;
     MMSKLGVLLT ICLLLFPLTA VPLDGDQHAD RPADRMQDIS SEQHPLFDPV KRCCDWPCTI
     GCVPCCLP