M2OM_DICDI
ID M2OM_DICDI Reviewed; 318 AA.
AC Q54PY7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Probable mitochondrial 2-oxoglutarate/malate carrier protein;
DE Short=OGCP;
DE AltName: Full=Mitochondrial substrate carrier family protein ucpC;
DE AltName: Full=Solute carrier family 25 member 11 homolog;
GN Name=ucpC; Synonyms=slc25a11; ORFNames=DDB_G0284225;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP REVIEW.
RX PubMed=17442478; DOI=10.1016/j.biochi.2007.03.004;
RA Satre M., Mattei S., Aubry L., Gaudet P., Pelosi L., Brandolin G.,
RA Klein G.;
RT "Mitochondrial carrier family: repertoire and peculiarities of the cellular
RT slime mould Dictyostelium discoideum.";
RL Biochimie 89:1058-1069(2007).
CC -!- FUNCTION: Mitochondrial solute carriers shuttle metabolites,
CC nucleotides, and cofactors through the mitochondrial inner membrane.
CC Catalyzes the transport of 2-oxoglutarate across the inner
CC mitochondrial membrane in an electroneutral exchange for malate or
CC other dicarboxylic acids, and plays an important role in several
CC metabolic processes, including the malate-aspartate shuttle, the
CC oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and
CC in nitrogen metabolism (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000064; EAL65301.1; -; Genomic_DNA.
DR RefSeq; XP_638658.1; XM_633566.1.
DR AlphaFoldDB; Q54PY7; -.
DR STRING; 44689.DDB0234071; -.
DR PaxDb; Q54PY7; -.
DR EnsemblProtists; EAL65301; EAL65301; DDB_G0284225.
DR GeneID; 8624487; -.
DR KEGG; ddi:DDB_G0284225; -.
DR dictyBase; DDB_G0284225; ucpC.
DR eggNOG; KOG0759; Eukaryota.
DR HOGENOM; CLU_015166_14_1_1; -.
DR InParanoid; Q54PY7; -.
DR OMA; KQGPLAF; -.
DR PhylomeDB; Q54PY7; -.
DR Reactome; R-DDI-1614517; Sulfide oxidation to sulfate.
DR Reactome; R-DDI-428643; Organic anion transporters.
DR Reactome; R-DDI-70263; Gluconeogenesis.
DR PRO; PR:Q54PY7; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:dictyBase.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006835; P:dicarboxylic acid transport; ISS:dictyBase.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..318
FT /note="Probable mitochondrial 2-oxoglutarate/malate carrier
FT protein"
FT /id="PRO_0000328692"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 22..111
FT /note="Solcar 1"
FT REPEAT 119..210
FT /note="Solcar 2"
FT REPEAT 219..309
FT /note="Solcar 3"
SQ SEQUENCE 318 AA; 35203 MW; C863FC6A4B9AAC49 CRC64;
MSSFNTQNKN VLQTPIPAPT PQSQLKQFVI GGLAGMLSSA FTHPIDSLKV RMQLQGEGTG
VGPKRGALKM LVHINQTEGF FTLYKGLSAS LLRQATYTTT RFGLYDLIKD IVAKDDKPLP
FTQKIMVGML SGAGGAIVGT PADLTMVRMQ ADGKLPFNLR RNYKNVFDGI FRISKEEGII
SLWKGCSPNL IRAMFMTAGQ VSSYDQTKQL MLASGYFHDD IKTHLIASTT AAFVAAVATS
PLDVIKTRIM NSPKTVTGEL QYKGTFDCLS KTLRAEGFKA FYKGFNPYFM RLGPQTILTF
IFVEQLNILW KKSQSYFK
