ID   M2OM_NEUCR              Reviewed;         331 AA.
AC   P0C582; A7UWG7; Q7S6P3; V5IKM2;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Putative mitochondrial 2-oxoglutarate/malate carrier protein;
DE            Short=OGCP;
DE   AltName: Full=Mitochondrial carrier 33;
GN   Name=mic-33; ORFNames=NCU04792, NCU10732;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Catalyzes the transport of 2-oxoglutarate across the inner
CC       mitochondrial membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; CM002241; ESA42143.1; -; Genomic_DNA.
DR   EMBL; CM002241; ESA42144.1; -; Genomic_DNA.
DR   RefSeq; XP_011395026.1; XM_011396724.1.
DR   RefSeq; XP_011395027.1; XM_011396725.1.
DR   AlphaFoldDB; P0C582; -.
DR   SMR; P0C582; -.
DR   STRING; 5141.EFNCRP00000004518; -.
DR   PRIDE; P0C582; -.
DR   EnsemblFungi; ESA42143; ESA42143; NCU10732.
DR   EnsemblFungi; ESA42144; ESA42144; NCU10732.
DR   GeneID; 5847541; -.
DR   KEGG; ncr:NCU10732; -.
DR   VEuPathDB; FungiDB:NCU10732; -.
DR   HOGENOM; CLU_015166_14_1_1; -.
DR   OMA; FLHTPFM; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015742; P:alpha-ketoglutarate transport; IEA:GOC.
DR   GO; GO:0071423; P:malate transmembrane transport; IEA:GOC.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="Putative mitochondrial 2-oxoglutarate/malate carrier
FT                   protein"
FT                   /id="PRO_0000295333"
FT   TRANSMEM        42..62
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..121
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          39..128
FT                   /note="Solcar 1"
FT   REPEAT          140..231
FT                   /note="Solcar 2"
FT   REPEAT          239..329
FT                   /note="Solcar 3"
SQ   SEQUENCE   331 AA;  35047 MW;  93F8659380392C45 CRC64;
     MSSVKQSAQA ATSDVVDTAK NATAETVTAA TDFLHTPAVR AALPFINGGL SGMVATTVIQ
     PIDMIKVRIQ LAGEGKAGGP KPTPLGVTRD IIASGKAMDL YTGLSAGLLR QAVYTTARIG
     CFDTFMSRLS ARAKEKGQSV GFKERASAGL AAGGLAAMIG NPADLALIRM QSDGLKPVAE
     RKNYKSVIDA LGGIARNEGV AALWAGAAPT VVRAMALNFG QLAFFSEAKA QLKARTQWSS
     KVQTLSASAI AGFFASFFSL PFDFVKTRLQ KQTRGPDGKL PYNGMVDCFA KVAKQEGVFR
     FYRGFGTYYV RIAPHAMVTL LVADYLGWLT K