M2OM_PIG
ID M2OM_PIG Reviewed; 333 AA.
AC F1RFX9;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2017, sequence version 2.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein;
DE Short=OGCP;
DE Short=alpha-oxoglutarate carrier;
DE AltName: Full=Solute carrier family 25 member 11;
DE Short=SLC25A11;
GN Name=SLC25A11 {ECO:0000312|VGNC:VGNC:92991};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc;
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND TRANSPORT ACTIVITY.
RX PubMed=4063354; DOI=10.1016/0005-2728(85)90222-1;
RA Bisaccia F., Indiveri C., Palmieri F.;
RT "Purification of reconstitutively active alpha-oxoglutarate carrier from
RT pig heart mitochondria.";
RL Biochim. Biophys. Acta 810:362-369(1985).
CC -!- FUNCTION: Catalyzes the transport of 2-oxoglutarate (alpha-
CC oxoglutarate) across the inner mitochondrial membrane in an
CC electroneutral exchange for malate (PubMed:4063354). Can also exchange
CC 2-oxoglutarate for other dicarboxylic acids such as malonate,
CC succinate, maleate and oxaloacetate, although with lower affinity
CC (PubMed:4063354). Contributes to several metabolic processes, including
CC the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in
CC gluconeogenesis from lactate, and in nitrogen metabolism (By
CC similarity). Maintains mitochondrial fusion and fission events, and the
CC organization and morphology of cristae (By similarity). Involved in the
CC regulation of apoptosis (By similarity). Helps protect from cytotoxic-
CC induced apoptosis by modulating glutathione levels in mitochondria (By
CC similarity). {ECO:0000250|UniProtKB:P22292,
CC ECO:0000250|UniProtKB:P97700, ECO:0000250|UniProtKB:Q02978,
CC ECO:0000250|UniProtKB:Q9CR62, ECO:0000269|PubMed:4063354}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-
CC oxoglutarate(in); Xref=Rhea:RHEA:71587, ChEBI:CHEBI:15589,
CC ChEBI:CHEBI:16810; Evidence={ECO:0000269|PubMed:4063354};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) +
CC malonate(out); Xref=Rhea:RHEA:71591, ChEBI:CHEBI:15792,
CC ChEBI:CHEBI:16810; Evidence={ECO:0000269|PubMed:4063354};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) +
CC succinate(out); Xref=Rhea:RHEA:71595, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:30031; Evidence={ECO:0000269|PubMed:4063354};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) +
CC maleate(out); Xref=Rhea:RHEA:71599, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:30780; Evidence={ECO:0000269|PubMed:4063354};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) +
CC oxaloacetate(out); Xref=Rhea:RHEA:71603, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:16810; Evidence={ECO:0000269|PubMed:4063354};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; AEMK02000082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9823.ENSSSCP00000018969; -.
DR PaxDb; F1RFX9; -.
DR PeptideAtlas; F1RFX9; -.
DR PRIDE; F1RFX9; -.
DR Ensembl; ENSSSCT00000019487.4; ENSSSCP00000018969.3; ENSSSCG00000032472.2.
DR VGNC; VGNC:92991; SLC25A11.
DR GeneTree; ENSGT00940000158465; -.
DR HOGENOM; CLU_015166_14_1_1; -.
DR InParanoid; F1RFX9; -.
DR TreeFam; TF354262; -.
DR Reactome; R-SSC-70263; Gluconeogenesis.
DR Proteomes; UP000008227; Chromosome 12.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000032472; Expressed in psoas major muscle and 41 other tissues.
DR ExpressionAtlas; F1RFX9; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:InterPro.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0006839; P:mitochondrial transport; IEA:InterPro.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002030; Mit_uncoupling_UCP-like.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Antiport; Lipid transport; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..333
FT /note="Mitochondrial 2-oxoglutarate/malate carrier protein"
FT /id="PRO_0000456255"
FT TRANSMEM 30..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..120
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..159
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..221
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..259
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..319
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 29..127
FT /note="Solcar"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 136..227
FT /note="Solcar"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT REPEAT 236..325
FT /note="Solcar"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 333 AA; 36777 MW; 53E5579FAF7B3F22 CRC64;
MQSWDPCLTP LELHGALFLH GPYWTPGLFR LIALGTCGDS CTHVRQPPKT WMGATVFVQP
LDLVKNRMQL SGEGAKTREY KTSFHALTSI LRAEGLRGIY TGLSAGLLRQ ATYTTTRLGI
YTVLFERLTG ADGTPPGFLL KALIGMTAGA TGAFVGTPAE VALIRMTADG RLPPDQRRGY
KNVFDALIRI VREEGVPTLW RGCIPTMARA VVVNAAQLAS YSQSKQFLLD SGYFSDNILC
HFCASMISGL VTTAASMPVD IAKTRIQNMR TIDGKPEYKN GLDVLVKVIR YEGFFSLWKG
FTPYYARLGP HTVLTFIFLE QMNKAYKRLF LSG
