ID   M2_VAR67                Reviewed;         220 AA.
AC   P0DOL7; P34017;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   02-DEC-2020, entry version 6.
DE   RecName: Full=Protein M2;
DE   Flags: Precursor;
GN   ORFNames=M2L, O2L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- SIMILARITY: Belongs to the poxviridae M2 protein family. {ECO:0000305}.
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DR   EMBL; X69198; CAA48960.1; -; Genomic_DNA.
DR   PIR; I36838; I36838.
DR   RefSeq; NP_042063.1; NC_001611.1.
DR   GeneID; 1486479; -.
DR   KEGG; vg:1486479; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR006971; Poxvirus_M2.
DR   Pfam; PF04887; Pox_M2; 1.
DR   PIRSF; PIRSF015982; VAC_M2L; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..220
FT                   /note="Protein M2"
FT                   /id="PRO_0000099631"
SQ   SEQUENCE   220 AA;  25212 MW;  38321DEDF3A1B78C CRC64;
     MVYKLVLLFC IASLGYSVEY KNTICPPRQD YRYWYFAAEL TIGVNYDINS TIIGECYMSE
     SYIDRNANIV LTGYGLEINM TIMDTDQRFV AAAEGVGKDN KLSVMLFTTQ RLDKVHHNIS
     VIITCMEMNC GTTKYNSDLP ESIHHKSSCD ITINGSCVTC VNLETDPTKI NPHYLHPKDK
     YLYHNSKYGM RGSYGVTFID ELNQCLLDIK ELSYDICYRE