ID   M2_VARV                 Reviewed;         220 AA.
AC   P0DOL8; P34017;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Protein M2;
DE   Flags: Precursor;
GN   ORFNames=M2L, O2L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Congo-1965;
RA   Massung R.F., Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M.,
RA   Totmenin A.V., Shchelkunov S.N., Esposito J.J.;
RL   Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the poxviridae M2 protein family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60767.1; -; Genomic_DNA.
DR   EMBL; U18337; AAA69324.1; -; Genomic_DNA.
DR   PIR; T28457; T28457.
DR   RefSeq; NP_042063.1; NC_001611.1.
DR   GeneID; 1486479; -.
DR   KEGG; vg:1486479; -.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR006971; Poxvirus_M2.
DR   Pfam; PF04887; Pox_M2; 1.
DR   PIRSF; PIRSF015982; VAC_M2L; 1.
PE   3: Inferred from homology;
KW   Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..220
FT                   /note="Protein M2"
FT                   /id="PRO_0000448208"
SQ   SEQUENCE   220 AA;  25212 MW;  38321DEDF3A1B78C CRC64;
     MVYKLVLLFC IASLGYSVEY KNTICPPRQD YRYWYFAAEL TIGVNYDINS TIIGECYMSE
     SYIDRNANIV LTGYGLEINM TIMDTDQRFV AAAEGVGKDN KLSVMLFTTQ RLDKVHHNIS
     VIITCMEMNC GTTKYNSDLP ESIHHKSSCD ITINGSCVTC VNLETDPTKI NPHYLHPKDK
     YLYHNSKYGM RGSYGVTFID ELNQCLLDIK ELSYDICYRE