ID   M34_CONMR               Reviewed;          68 AA.
AC   P0C1N3;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Conotoxin Mr3.4;
DE   Flags: Precursor;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15924437; DOI=10.1021/bi047541b;
RA   Corpuz G.P., Jacobsen R.B., Jimenez E.C., Watkins M., Walker C.,
RA   Colledge C., Garrett J.E., McDougal O., Li W., Gray W.R., Hillyard D.R.,
RA   Rivier J., McIntosh J.M., Cruz L.J., Olivera B.M.;
RT   "Definition of the M-conotoxin superfamily: characterization of novel
RT   peptides from molluscivorous Conus venoms.";
RL   Biochemistry 44:8176-8186(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C1N3; -.
DR   ConoServer; 1469; Mr3.4 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   InterPro; IPR018072; Conotoxin_a-typ_CS.
DR   Pfam; PF02950; Conotoxin; 1.
DR   PROSITE; PS60014; ALPHA_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hydroxylation; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000246043"
FT   PEPTIDE         50..68
FT                   /note="Conotoxin Mr3.4"
FT                   /id="PRO_0000246044"
FT   MOD_RES         65
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        54..63
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        59..66
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   68 AA;  7652 MW;  2EE55923B9D7285D CRC64;
     MSKLGVLLTI CLLLFPLTAV PLDGDQPADR PAERMQDDIS SERHPFFDRS KQCCHLPACR
     FGCTPCCW