ID   M35_MUHVK               Reviewed;         519 AA.
AC   A8E1G1;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Protein M35;
GN   Name=M35;
OS   Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=69156;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15709020; DOI=10.1128/jvi.79.5.2998-3008.2005;
RA   Redwood A.J., Messerle M., Harvey N.L., Hardy C.M., Kozinowski U.H.,
RA   Lawson M.A., Shellam G.R.;
RT   "Use of a murine cytomegalovirus K181-derived bacterial artificial
RT   chromosome as a vaccine vector for immunocontraception.";
RL   J. Virol. 79:2998-3008(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18417589; DOI=10.1128/jvi.00160-08;
RA   Smith L.M., McWhorter A.R., Masters L.L., Shellam G.R., Redwood A.J.;
RT   "Laboratory strains of murine cytomegalovirus are genetically similar to
RT   but phenotypically distinct from wild strains of virus.";
RL   J. Virol. 82:6689-6696(2008).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28542326; DOI=10.1371/journal.ppat.1006382;
RA   Chan B., Goncalves Magalhaes V., Lemmermann N.A.W., Juranic Lisnic V.,
RA   Stempel M., Bussey K.A., Reimer E., Podlech J., Lienenklaus S.,
RA   Reddehase M.J., Jonjic S., Brinkmann M.M.;
RT   "The murine cytomegalovirus M35 protein antagonizes type I IFN induction
RT   downstream of pattern recognition receptors by targeting NF-kappaB mediated
RT   transcription.";
RL   PLoS Pathog. 13:E1006382-E1006382(2017).
CC   -!- FUNCTION: Plays a role in the inhibition of host type I interferon
CC       production within the host nucleus. Targets specifically the NF-kappa-
CC       B-mediated interferon-beta transcription.
CC       {ECO:0000269|PubMed:28542326}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:28542326}.
CC       Note=Found in the host nucleus but is excluded from the nucleoli.
CC       {ECO:0000269|PubMed:28542326}.
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DR   EMBL; AM886412; CAP08082.1; -; Genomic_DNA.
DR   SMR; A8E1G1; -.
DR   Proteomes; UP000158680; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006731; Herpes_pp85.
DR   Pfam; PF04637; Herpes_pp85; 1.
PE   4: Predicted;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..519
FT                   /note="Protein M35"
FT                   /id="PRO_0000442578"
FT   REGION          485..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   519 AA;  58108 MW;  E9DBF8A627CD05A0 CRC64;
     MAAPTEEDPR RDTSLMINER CNFPHNMLSE ENINFIQDAV CNGDLGAVAA LNSGLPMAPY
     MLEALLAVRV KHRLTKVRQT LEPVICYTIS VAHLINGTRI LRSATAKHAT AWGPNDKHRA
     ESGLRRIYRA LNLEDNPFDL VEAVGDLDLS QGAYEGYVRH IYSLMKSLGH DVGHLSRSLD
     YSTMTVFNYL YESPLFTSQE AVTMYSRNLA GITKMSREPF ETLSVVHRSK EPPEILNDML
     FLLSVGRMIV LHQESLRALR KNLILTASAL CSILYTAYTQ VPETKSLFRE VAHEAHALLS
     SRSPDTPNFR PFVACMLQFI KQIIAADVYT CPRYLTNQIL AVTARMHGLE GAAMGHDDDL
     DIEVDPGNPY SAKYRMNNPY NDQNIFKCPR SLVHYVGDAL FKKTMTQELL VSCTDQEATY
     QTYELPSVSE LVGEGVAKRA HLTPDQLSHY LSVVSTPVEV VTDDIEDGEQ EEDLFADVSV
     APASPVRPIR GGGQRMANMR GARPYSTVQR GRRRHESEV