ID   M3A_CONPE               Reviewed;          17 AA.
AC   P0DL85;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2017, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Conotoxin Pn3a {ECO:0000303|PubMed:28831846};
OS   Conus pennaceus (Feathered cone) (Conus episcopus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Darioconus.
OX   NCBI_TaxID=37335;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, BIOASSAY, MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, AND SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=28831846; DOI=10.1080/09168451.2017.1364966;
RA   Abdel-Wahab M., Miyashita M., Ota Y., Juichi H., Okabe R., Sarhan M.,
RA   Fouda M., Abdel-Rahman M., Saber S., Nakagawa Y.;
RT   "Isolation, structural identification and biological characterization of
RT   two conopeptides from the Conus pennaceus venom.";
RL   Biosci. Biotechnol. Biochem. 81:2086-2089(2017).
CC   -!- FUNCTION: May act as a neurotoxin (By similarity). Has no activity on
CC       mollusks (tested on the freshwater snail C.retropictus)
CC       (PubMed:28831846). {ECO:0000250|UniProtKB:P0C1M9,
CC       ECO:0000269|PubMed:28831846}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28831846}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:28831846}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1851.6; Method=Electrospray; Note=Monoisotopic
CC       mass.; Evidence={ECO:0000269|PubMed:28831846};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DL85; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..17
FT                   /note="Conotoxin Pn3a"
FT                   /evidence="ECO:0000269|PubMed:28831846"
FT                   /id="PRO_0000442775"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        3..12
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        8..15
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   17 AA;  1859 MW;  78FA31FC579982A4 CRC64;
     GCCHLLACRF GCSPCCW