ID   M3A_CONQU               Reviewed;          15 AA.
AC   P58841;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 1.
DT   22-APR-2020, entry version 48.
DE   RecName: Full=Conotoxin QcIIIA;
OS   Conus quercinus (Oak cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=101313;
RN   [1]
RP   PROTEIN SEQUENCE, HYDROXYLATION AT PRO-11, AND AMIDATION AT ASN-15.
RX   PubMed=2165278; DOI=10.1126/science.2165278;
RA   Olivera B.M., Rivier J., Clark C., Ramilo C.A., Corpuz G.P., Abogadie F.C.,
RA   Mena E.E., Woodward S.R., Hillyard D.R., Cruz L.J.;
RT   "Diversity of Conus neuropeptides.";
RL   Science 249:257-263(1990).
CC   -!- FUNCTION: Causes scratching in mice.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues.
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   ConoServer; 1514; QcIIIA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..15
FT                   /note="Conotoxin QcIIIA"
FT                   /id="PRO_0000044501"
FT   MOD_RES         11
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:2165278"
FT   MOD_RES         15
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000269|PubMed:2165278"
FT   DISULFID        1..13
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        2..9
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        6..12
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   15 AA;  1601 MW;  D479B5AEB4ED832D CRC64;
     CCSQDCLVCI PCCPN