ID   M3B_CONMR               Reviewed;          19 AA.
AC   P0C1N0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Conotoxin mr3b {ECO:0000303|PubMed:15924437, ECO:0000303|PubMed:17042781};
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, HYDROXYLATION AT PRO-16, BIOASSAY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=15924437; DOI=10.1021/bi047541b;
RA   Corpuz G.P., Jacobsen R.B., Jimenez E.C., Watkins M., Walker C.,
RA   Colledge C., Garrett J.E., McDougal O., Li W., Gray W.R., Hillyard D.R.,
RA   Rivier J., McIntosh J.M., Cruz L.J., Olivera B.M.;
RT   "Definition of the M-conotoxin superfamily: characterization of novel
RT   peptides from molluscivorous Conus venoms.";
RL   Biochemistry 44:8176-8186(2005).
RN   [2]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND BIOASSAY.
RC   TISSUE=Venom;
RX   PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA   Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA   Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT   "Characterization of novel M-superfamily conotoxins with new disulfide
RT   linkage.";
RL   FEBS J. 273:4972-4982(2006).
CC   -!- FUNCTION: Intracranial injection into mice causes scratching and
CC       hyperactivity. {ECO:0000269|PubMed:15924437,
CC       ECO:0000269|PubMed:17042781}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15924437}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:15924437}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2126.9; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:15924437};
CC   -!- MASS SPECTROMETRY: Mass=2125.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17042781};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C1N0; -.
DR   ConoServer; 1465; MrIIIB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..19
FT                   /note="Conotoxin mr3b"
FT                   /evidence="ECO:0000269|PubMed:15924437,
FT                   ECO:0000269|PubMed:17042781"
FT                   /id="PRO_0000246038"
FT   MOD_RES         16
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:15924437"
FT   DISULFID        4..18
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        5..14
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        10..17
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   19 AA;  2118 MW;  61EC12E4BA8982A4 CRC64;
     SKQCCHLAAC RFGCTPCCW