M3C_CONMR
ID M3C_CONMR Reviewed; 16 AA.
AC P0C424;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Conotoxin mr3c;
OS Conus marmoreus (Marble cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX NCBI_TaxID=42752;
RN [1]
RP PROTEIN SEQUENCE, HYDROXYLATION AT PRO-13, MASS SPECTROMETRY, AND BIOASSAY.
RC TISSUE=Venom;
RX PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT "Characterization of novel M-superfamily conotoxins with new disulfide
RT linkage.";
RL FEBS J. 273:4972-4982(2006).
CC -!- FUNCTION: Intracranially injection into mice does not elicit symptoms.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 2 branch, since 2 residues stand between the fourth and the fifth
CC cysteine residues.
CC -!- MASS SPECTROMETRY: Mass=1707.6; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:17042781};
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C424; -.
DR ConoServer; 1486; MrIIIC.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hydroxylation; Neurotoxin;
KW Secreted; Toxin.
FT PEPTIDE 1..16
FT /note="Conotoxin mr3c"
FT /id="PRO_0000289865"
FT MOD_RES 13
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:17042781"
FT DISULFID 1..15
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT DISULFID 2..11
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT DISULFID 7..14
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ SEQUENCE 16 AA; 1699 MW; 8E5661E4EE4EEFAA CRC64;
CCAPSACRLG CRPCCR