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M3C_CONMR
ID   M3C_CONMR               Reviewed;          16 AA.
AC   P0C424;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Conotoxin mr3c;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   PROTEIN SEQUENCE, HYDROXYLATION AT PRO-13, MASS SPECTROMETRY, AND BIOASSAY.
RC   TISSUE=Venom;
RX   PubMed=17042781; DOI=10.1111/j.1742-4658.2006.05493.x;
RA   Han Y.-H., Wang Q., Jiang H., Liu L., Xiao C., Yuan D.-D., Shao X.-X.,
RA   Dai Q.-Y., Cheng J.-S., Chi C.-W.;
RT   "Characterization of novel M-superfamily conotoxins with new disulfide
RT   linkage.";
RL   FEBS J. 273:4972-4982(2006).
CC   -!- FUNCTION: Intracranially injection into mice does not elicit symptoms.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues.
CC   -!- MASS SPECTROMETRY: Mass=1707.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17042781};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C424; -.
DR   ConoServer; 1486; MrIIIC.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..16
FT                   /note="Conotoxin mr3c"
FT                   /id="PRO_0000289865"
FT   MOD_RES         13
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:17042781"
FT   DISULFID        1..15
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        2..11
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        7..14
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   16 AA;  1699 MW;  8E5661E4EE4EEFAA CRC64;
     CCAPSACRLG CRPCCR
 
 
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