ID   M3E_CONAO               Reviewed;          16 AA.
AC   C0HKY9;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin ar3e {ECO:0000303|PubMed:26100663};
OS   Conus araneosus (Cobweb cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=101286;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=26100663; DOI=10.1016/j.toxicon.2015.06.017;
RA   Franklin J.B., Rajesh R.P.;
RT   "A sleep-inducing peptide from the venom of the Indian cone snail Conus
RT   araneosus.";
RL   Toxicon 103:39-47(2015).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26100663}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:26100663}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1613.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:26100663};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKY9; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..16
FT                   /note="Conotoxin ar3e"
FT                   /evidence="ECO:0000269|PubMed:26100663"
FT                   /id="PRO_0000441665"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        3..12
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        8..15
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   UNSURE          4
FT                   /note="I or L"
FT                   /evidence="ECO:0000305|PubMed:26100663"
FT   UNSURE          5
FT                   /note="I or L"
FT                   /evidence="ECO:0000305|PubMed:26100663"
FT   UNSURE          14
FT                   /note="I or L"
FT                   /evidence="ECO:0000305|PubMed:26100663"
SQ   SEQUENCE   16 AA;  1622 MW;  4DA67B1ED9C7A40C CRC64;
     DCCIIAGCPF GCTICC