ID   M3I_CONAO               Reviewed;          16 AA.
AC   C0HKZ3;
DT   27-SEP-2017, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin ar3i {ECO:0000303|PubMed:26100663};
DE   AltName: Full=Conotoxin ar3j {ECO:0000303|PubMed:26100663};
OS   Conus araneosus (Cobweb cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=101286;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLU-1.
RC   TISSUE=Venom;
RX   PubMed=26100663; DOI=10.1016/j.toxicon.2015.06.017;
RA   Franklin J.B., Rajesh R.P.;
RT   "A sleep-inducing peptide from the venom of the Indian cone snail Conus
RT   araneosus.";
RL   Toxicon 103:39-47(2015).
CC   -!- FUNCTION: Has a sleep-inducing effect in mice when injected
CC       intraperitoneally. {ECO:0000269|PubMed:26100663}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26100663}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:26100663}.
CC   -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC       2 branch, since 2 residues stand between the fourth and the fifth
CC       cysteine residues. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=1841.0; Method=MALDI; Note=Pyrolutamate
CC       modification.; Evidence={ECO:0000269|PubMed:26100663};
CC   -!- MASS SPECTROMETRY: Mass=1859.0; Method=MALDI; Note=No pyrolutamate
CC       modification.; Evidence={ECO:0000269|PubMed:26100663};
CC   -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKZ3; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..16
FT                   /note="Conotoxin ar3i"
FT                   /evidence="ECO:0000269|PubMed:26100663"
FT                   /id="PRO_0000441667"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid (Glu); partial"
FT                   /evidence="ECO:0000269|PubMed:26100663"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        3..12
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
FT   DISULFID        8..15
FT                   /evidence="ECO:0000250|UniProtKB:P0CI24"
SQ   SEQUENCE   16 AA;  1867 MW;  7CD5B1B19470B9CE CRC64;
     ECCRYVDCRR GCTPCC