M3I_CONTE
ID M3I_CONTE Reviewed; 15 AA.
AC P0DPL2;
DT 12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 1.
DT 22-APR-2020, entry version 5.
DE RecName: Full=Conotoxin tx3i {ECO:0000305};
OS Conus textile (Cloth-of-gold cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=6494;
RN [1]
RP PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP LOCATION, HYDROXYLATION AT PRO-4, HYDROXYLATION AT PRO-13, AND AMIDATION AT
RP CYS-15.
RC TISSUE=Venom;
RX PubMed=22709442; DOI=10.1021/pr300312h;
RA Bhatia S., Kil Y.J., Ueberheide B., Chait B.T., Tayo L., Cruz L., Lu B.,
RA Yates J.R. III, Bern M.;
RT "Constrained de novo sequencing of conotoxins.";
RL J. Proteome Res. 11:4191-4200(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22709442}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:22709442}.
CC -!- DOMAIN: The cysteine framework is III (CC-C-C-CC). Classified in the M-
CC 2 branch, since 2 residues stand between the fourth and the fifth
CC cysteine residues. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin M superfamily. {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW Secreted; Toxin.
FT PEPTIDE 1..15
FT /note="Conotoxin tx3i"
FT /evidence="ECO:0000269|PubMed:22709442"
FT /id="PRO_0000445048"
FT MOD_RES 4
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:22709442"
FT MOD_RES 13
FT /note="4-hydroxyproline; partial"
FT /evidence="ECO:0000269|PubMed:22709442"
FT MOD_RES 15
FT /note="Cysteine amide"
FT /evidence="ECO:0000269|PubMed:22709442"
FT DISULFID 1..15
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT DISULFID 2..11
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT DISULFID 7..14
FT /evidence="ECO:0000250|UniProtKB:P0CI24"
FT UNSURE 8
FT /note="I or L"
FT /evidence="ECO:0000305|PubMed:22709442"
SQ SEQUENCE 15 AA; 1430 MW; 1161E2227971A05F CRC64;
CCGPTACIAG CKPCC