M3K19_MOUSE
ID M3K19_MOUSE Reviewed; 1311 AA.
AC E9Q3S4;
DT 06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Mitogen-activated protein kinase kinase kinase 19;
DE EC=2.7.11.1;
DE AltName: Full=SPS1/STE20-related protein kinase YSK4;
GN Name=Map3k19; Synonyms=Ysk4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1;
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily. {ECO:0000305}.
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DR EMBL; AC121883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC163690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_035867.1; NM_011737.1.
DR AlphaFoldDB; E9Q3S4; -.
DR SMR; E9Q3S4; -.
DR BioGRID; 204617; 1.
DR IntAct; E9Q3S4; 1.
DR STRING; 10090.ENSMUSP00000056254; -.
DR iPTMnet; E9Q3S4; -.
DR PhosphoSitePlus; E9Q3S4; -.
DR MaxQB; E9Q3S4; -.
DR PaxDb; E9Q3S4; -.
DR PRIDE; E9Q3S4; -.
DR ProteomicsDB; 292136; -.
DR Antibodypedia; 2102; 57 antibodies from 19 providers.
DR DNASU; 22625; -.
DR Ensembl; ENSMUST00000061512; ENSMUSP00000056254; ENSMUSG00000051590.
DR GeneID; 22625; -.
DR KEGG; mmu:22625; -.
DR UCSC; uc011wra.1; mouse.
DR CTD; 80122; -.
DR MGI; MGI:1203481; Map3k19.
DR VEuPathDB; HostDB:ENSMUSG00000051590; -.
DR eggNOG; KOG0198; Eukaryota.
DR GeneTree; ENSGT00940000160383; -.
DR InParanoid; E9Q3S4; -.
DR OMA; RNMCSFQ; -.
DR PhylomeDB; E9Q3S4; -.
DR TreeFam; TF332735; -.
DR BioGRID-ORCS; 22625; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Map3k19; mouse.
DR PRO; PR:E9Q3S4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; E9Q3S4; protein.
DR Bgee; ENSMUSG00000051590; Expressed in fourth ventricle and 29 other tissues.
DR ExpressionAtlas; E9Q3S4; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..1311
FT /note="Mitogen-activated protein kinase kinase kinase 19"
FT /id="PRO_0000421022"
FT DOMAIN 1044..1307
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 85..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1169
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 1050..1058
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 1072
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 1311 AA; 146412 MW; C69E361F52305D44 CRC64;
MDSMPRPERH AESLLDICHE AGSTPMEMTV SQTENLTLQS ISSSEDFDLE DDFSPFILAR
EGAAPRGENW PRRTEGVEII VTFPPDPLQE ASQEDLKESN QVTSEHQERE QVHPVSPPDD
AEMVGLTGRM LTTQPSLLKT DGSSEELCGV DVALSPPRPC LDSSLAASAA GEVAPCVLKE
QQRQSDEFPT SDISYSSRRT GLPLPPLSCL PMRSCIFNME KSPKSPRHRE RKVPSLSLSV
PKLLEPLSRP LSQSAEFSSS KNHQEVTQEG PVEHTLRGSN CTLWSRNMCS FRKSGKQGVA
ESWPSQEMEG WDKTKTSGFK EGPSLFSCES VKEDTTPTER ERDSGYHVSE MQRGGEDSQY
LSSRKKESWT ARVVERDSGV EHPILCKLLE VSNSEMTPAE EKEIGNENVP DAKSNSVHKS
GAMEPHAASE EVSVPKNGPS VNSDGPAEEL EGHRDIEQNR KIPMEEETNP EMNGVVPLTH
IAFPGEGTSK GPARAEPHLQ RRKRPAQNSN SFNLLAHREH DKLQTNTHRT KLDSRTKARN
RAPPNLMVSI QASIKPNMHK NSIKTQVFPA LELIDHRPHP SSKFQRRAPL TEKKSTHQTQ
KPKKQAFPRI GKHAGIKKPG IPLSAETTDP RLHFLDLKYS DMFKEINSAS NGPGIYEMFG
TPVYCHIREA ERHDHRCYRE IRTAPSGRCV VNKCQSSESD RCSNSRARLL QKRQHIKPPK
PLHGLRQKHR GFISKDKGCK DMGGHTEDSV SEPDGQMKSP GNDFLSSKDD AQLMHLIPIP
ELSPEQKAPA PVSDLSIVEE IFTEECADEE GILNDDSLTQ SLGDLKEPEG LHPQAPLVPS
ENSWAVLSEK RSGKRVSPEK HNVEPLDKIN AEQMFPGYLE FDSLSEKSKT LVSFSSCSFQ
ENLERAPSPT EQHWARSLEQ DSLENNSTTY QTFGKISQEI LDPGKNEELT DELLGCLVEE
LLALDEKDNN SCQIMTNEAD AKNLNLVFSR RGNTIEELGR ETTDVKLQRC INGFRIYDEE
NFLTSNEKKT LSDKSLNHEE AIFWTKGEIL GRGAYGTVYC GLTSLGQLIA VKQVALDTSD
KLATEKEYRK LQEEVDLLKA LKHVNIVAYL GTCLEENTLS IFMEFVPGGS ISSIINRFGP
LPEMVFCKYT RQILQGVAYL HDNCVVHRDI KGNNVMLMPT GIIKLIDFGC AKRLAWAGLN
GTHSDMLKSM RGTPYWMAPE VINESGYGRK SDIWSIGCTV FEMATGKPPL ASMDRMAAMF
YIGAHRGLMP PLPARFSEPA ADFVRLCLTR DQHERPSALQ LLKHSFLKRS Q
